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Review
. 2022 Oct 5;11(10):1983.
doi: 10.3390/antiox11101983.

The Impact of Oxidative Stress on Pediatrics Syndromes

Ginevra Micangeli  1 , Michela Menghi  1 , Giovanni Profeta  1 , Francesca Tarani  1 , Alessandro Mariani  2 , Carla Petrella  3 , Christian Barbato  3 , Giampiero Ferraguti  4 , Mauro Ceccanti  5   6 , Luigi Tarani  1 , Marco Fiore  3
Affiliations
Review

The Impact of Oxidative Stress on Pediatrics Syndromes

Ginevra Micangeli et al. Antioxidants (Basel). .

Abstract

Oxidative stress is a condition determined by an imbalance between antioxidant and oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed, it causes both necrosis and cell apoptosis, determining cellular aging, increased carcinogenesis, vascular stiffening, increased autoimmune diseases, and muscle decay. In the context of pediatric syndromes, oxidative stress could play a role in the first order. In fact, our review of the literature showed that in some pathologies, such as fetal alcohol spectrum disorders, oxidative stress related to the intake of ethanol during pregnancy is a main etiological factor determining the associated clinical syndrome. On the contrary, in Williams syndrome, Down syndrome, Marfan syndrome, Gaucher syndrome, ataxia-telangiectasia, autistic spectrum disorder, Fanconi's anemia, and primitive immunodeficiencies, the increase in oxidative stress is directly associated with the genetic alterations that cause the same pathologies. Although further studies are needed to better understand the relationship between oxidative stress and pediatric diseases, a better knowledge of this crucial issue encourages future therapeutic strategies.

Keywords: FASD; antioxidant; genetic syndrome; oxidative stress; pediatrics.

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Conflict of interest statement

The authors declare no conflict of interest, financial or otherwise.

Figures

Figure 1
Figure 1
The figure shows the oxidative imbalance between ROS and antioxidant factors that leads to oxidative stress and the related consequences on the cell.
See this image and copyright information in PMC

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