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Review
. 2022 Sep 6:9:986423.
doi: 10.3389/fcvm.2022.986423. eCollection 2022.

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Lan Wu  1   2 , Zhizheng Li  3 , Yanfei Li  1   3
Affiliations
Review

The crosstalk between STAT3 and microRNA in cardiac diseases and protection

Lan Wu et al. Front Cardiovasc Med. .

Abstract

Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic genes but suppresses anti-inflammatory and anti-fibrotic genes in cardiac disease and protection. As a signaling molecule, STAT3 is the downstream or upstream of other molecules for signaling transduction, also activated in cardiac disease and protection. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that regulate mRNA expression at the transcriptional level and prevent protein translation. Recently, STAT3 is reported to be not only the target of miRNA but also the inhibitor or inducer of miRNA to modify the mRNA expression profiles in cardiomyocytes resulting in different effects on cardiac disease and protection. We summarize the current knowledge on STAT3 regulation of individual miRNAs and the modulation of STAT3 by miRNAs in cardiac diseases and protection.

Keywords: cardiac diseases; cardioprotection; crosstalk; microRNA; signal transducer and activator of transcription 3.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
STAT3-miRNA crosstalk. STAT3, Signal Transducer and Activator of Transcription 3; P-STAT3, phosphorylation of STAT3; miRNA, MicroRNA; lncRNA, Long non-coding RNA; MI, Myocardial infarction; DCM, Dilated cardiomyopathy; RHD, Rheumatic heart disease; HC, Hypertrophic cardiomyopathy; SC, Septic cardiomyopathy; DIC, Drug-induced cardiomyopathy; PPCM, Peripartum cardiomyopathy.
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