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. 2022 Oct;16(5):2141-2149.
doi: 10.1007/s11682-022-00684-z. Epub 2022 Jul 26.

Reduced structural integrity of the uncinate fasciculus in incarcerated women scoring high on psychopathy

J Michael Maurer  1 , Subhadip Paul  2   3   4 , Bethany G Edwards  5   6 , Nathaniel E Anderson  5 , Prashanth K Nyalakanti  5 , Carla L Harenski  5 , Jean Decety  7 , Kent A Kiehl  8   9
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Reduced structural integrity of the uncinate fasciculus in incarcerated women scoring high on psychopathy

J Michael Maurer et al. Brain Imaging Behav. 2022 Oct.

Abstract

Both men and women scoring high on psychopathy exhibit similar structural and functional neural abnormalities, including reduced volume of the orbitofrontal cortex (OFC) and reduced hemodynamic activity in the amygdala during affective processing experimental paradigms. The uncinate fasciculus (UF) is a white matter (WM) tract that connects the amygdala to the OFC. Reduced structural integrity of the UF, measured via fractional anisotropy (FA), is commonly associated with men scoring high on psychopathy. However, only one study to date has investigated the relationship between psychopathic traits and UF structural integrity in women, recruiting participants from a community sample. Here, we investigated whether Hare Psychopathy Checklist-Revised (PCL-R) facet scores (measuring interpersonal, affective, lifestyle/behavioral, and antisocial psychopathic traits, respectively) were associated with reduced FA in the left and right UF in a sample of 254 incarcerated women characterized by a wide range of psychopathy scores. We observed that PCL-R Facet 3 scores, assessing lifestyle/behavioral psychopathic traits, were associated with reduced FA in the left and right UF, even when controlling for participant's age and history of previous substance use. The results obtained in the current study help improve our understanding of structural abnormalities associated with women scoring high on psychopathy. Specifically, reduced UF structural integrity may contribute to some of the deficits commonly associated with women scoring high on psychopathy, including emotion dysregulation.

Keywords: Diffusion tensor imaging; Female psychopathy; Fractional anisotropy; Uncinate fasciculus.

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