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Review
. 2022 Sep;100(9):415-432.
doi: 10.1111/avj.13179. Epub 2022 Jun 16.

Hyperthyroid cats and their kidneys: a literature review

L Yu  1 , L Lacorcia  1 , T Johnstone  2
Affiliations
Review

Hyperthyroid cats and their kidneys: a literature review

L Yu et al. Aust Vet J. 2022 Sep.

Abstract

Hyperthyroidism and chronic kidney disease (CKD) are common diseases of geriatric cats, and often occur concurrently. Thus, a thorough understanding of the influence of thyroid function on renal function is of significant value for all feline practitioners. Among other effects, hyperthyroidism causes protein catabolism and increases renal blood flow and glomerular filtration rate (GFR). These effects render traditional renal markers insensitive for the detection of CKD in cats with uncontrolled hyperthyroidism. Furthermore, the development of iatrogenic hypothyroidism with over treatment of hyperthyroidism can be detrimental to renal function and may negatively affect long-term survival. This review discusses important diagnostic considerations of feline hyperthyroidism, as well as key treatment modalities, with an emphasis on the use of radioiodine and the importance of post treatment monitoring of thyroid and renal parameters. In Australia, a common curative treatment for cats with benign hyperthyroidism (i.e. thyroid hyperplasia or adenoma) is a fixed dose of orally administered radioiodine, regardless of the serum total thyroxine concentration at the time of diagnosis. This review discusses the long term outcomes of this standard of care in comparison with current, relevant research literature from around the world. Finally, this review explores the use of symmetric dimethylarginine (SDMA) in assessing renal function before and after treatment in hyperthyroid cats. SDMA correlates well with GFR and creatinine in non-hyperthyroid cats, but our understanding of its performance in hyperthyroid cats remains in its infancy.

Keywords: I-131; SDMA; chronic kidney disease; feline hyperthyroidism; radioiodine; renal azotaemia; symmetric dimethylarginine.

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Conflict of interest statement

The authors declare no conflicts of interest or sources of funding for the work presented here.

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References

    1. Scott‐Moncrieff JC. Feline hyperthyroidism. In: Feldman EC, Nelson RW, Reusch C, Scott‐Moncrieff JC, editors. Canine and feline endocrinology. Fourth edn. Elsevier Saunders, St. Louis, Missouri, 2015;137–187.
    1. McLean JL, Lobetti RG, Schoeman JP. Worldwide prevalence and risk factors for feline hyperthyroidism: a review. J S Afr Vet Assoc 2014;85:1097. 10.4102/jsava.v85i1.1097. - DOI - PubMed
    1. Turrel JM, Feldman EC, Nelson RW et al. Thyroid carcinoma causing hyperthyroidism in cats: 14 cases (1981‐1986). J Am Vet Med Assoc 1988;193:359–365. - PubMed
    1. Hibbert A, Gruffydd‐Jones T, Barrett EL et al. Feline thyroid carcinoma: diagnosis and response to high‐dose radioactive iodine treatment. J Feline Med Surg 2009;11:116–124. 10.1016/j.jfms.2008.02.010. - DOI - PubMed
    1. Peterson ME, Broome MR, Rishniw M. Prevalence and degree of thyroid pathology in hyperthyroid cats increases with disease duration: a cross‐sectional analysis of 2096 cats referred for radioiodine therapy. J Feline Med Surg 2016;18:92–103. 10.1177/1098612X15572416. - DOI - PubMed

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