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Review
. 2022:56:319-332.
doi: 10.1007/7854_2022_366.

Psilocybin for Trauma-Related Disorders

Amanda J Khan  1 , Ellen Bradley  1 , Aoife O'Donovan  1 , Joshua Woolley  2
Affiliations
Review

Psilocybin for Trauma-Related Disorders

Amanda J Khan et al. Curr Top Behav Neurosci. 2022.

Abstract

Posttraumatic stress disorder (PTSD) is a debilitating, chronic disorder and efficacy rates of current PTSD treatments are underwhelming. There is a critical need for innovative approaches. We provide an overview of trauma and PTSD and cite literature providing converging evidence of the therapeutic potential of psilocybin for PTSD. No study to date has investigated psilocybin or psilocybin-assisted psychotherapy (PAP) as treatments for PTSD. An open-label study in traumatized AIDS survivors found that PAP reduced PTSD symptoms, attachment anxiety, and demoralization. Several PAP trials show preliminary efficacy in facilitating confronting traumatic memories, decreasing emotional avoidance, depression, anxiety, pessimism, and disconnection from others, and increasing acceptance, self-compassion, and forgiveness of abusers, all of which are relevant to PTSD recovery. There is also early evidence that other classic psychedelics may produce large reductions in PTSD symptoms in combat veterans. However, this body of literature is small, mechanisms are not yet well understood, and the risks of using psychedelic compounds for trauma-related disorders need further study. In sum, evidence supports further investigation of PAP as a radically new approach for treating PTSD.

Keywords: Posttraumtic Stress Disorder; Psilocybin; Psychedelics; Trauma; Treatment.

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References

    1. Agin-Liebes G, Haas TF, Lancelotta R, Uthaug MV, Davis JGRAK (2021) Naturalistic use of mescaline is associated with self-reported psychiatric improvements and enduring positive life changes. ACS Pharmacol Trans Sci 4(2):543–552. https://doi.org/10.1021/acsptsci.1c00018 - DOI
    1. Akiki TJ, Averill CL, Abdallah CG (2017) A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies. Curr Psychiatry Rep 19(11):81 - PubMed - PMC - DOI
    1. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders: DSM-5, 5th edn. American Psychiatric Publishing, Washington - DOI
    1. Anderson BT, Danforth A, Daroff R et al (2020) Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: an open-label safety and feasibility pilot study. EClinicalMedicine 27:100538 - PubMed - PMC - DOI
    1. Argento E, Strathdee SA, Tupper K et al (2017) Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting. BMJ Open 7(9):e016025 - PubMed - PMC - DOI

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