Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade
- PMID: 35563414
- PMCID: PMC9103893
- DOI: 10.3390/ijms23095023
Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade
Abstract
Positron emission tomography (PET) uses radioactive tracers and enables the functional imaging of several metabolic processes, blood flow measurements, regional chemical composition, and/or chemical absorption. Depending on the targeted processes within the living organism, different tracers are used for various medical conditions, such as cancer, particular brain pathologies, cardiac events, and bone lesions, where the most commonly used tracers are radiolabeled with 18F (e.g., [18F]-FDG and NA [18F]). Oxygen-15 isotope is mostly involved in blood flow measurements, whereas a wide array of 11C-based compounds have also been developed for neuronal disorders according to the affected neuroreceptors, prostate cancer, and lung carcinomas. In contrast, the single-photon emission computed tomography (SPECT) technique uses gamma-emitting radioisotopes and can be used to diagnose strokes, seizures, bone illnesses, and infections by gauging the blood flow and radio distribution within tissues and organs. The radioisotopes typically used in SPECT imaging are iodine-123, technetium-99m, xenon-133, thallium-201, and indium-111. This systematic review article aims to clarify and disseminate the available scientific literature focused on PET/SPECT radiotracers and to provide an overview of the conducted research within the past decade, with an additional focus on the novel radiopharmaceuticals developed for medical imaging.
Keywords: PET; SPECT; molecular imaging; radiopharmaceuticals; review; tracers.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
More advantages in detecting bone and soft tissue metastases from prostate cancer using 18F-PSMA PET/CT.Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7. Hell J Nucl Med. 2019. PMID: 30843003
-
Magnetic resonance imaging (MRI) for the assessment of myocardial viability: an evidence-based analysis.Ont Health Technol Assess Ser. 2010;10(15):1-45. Epub 2010 Jul 1. Ont Health Technol Assess Ser. 2010. PMID: 23074392 Free PMC article.
-
Nuclear medicine imaging in tuberculosis using commercially available radiopharmaceuticals.Nucl Med Commun. 2012 Jun;33(6):581-90. doi: 10.1097/MNM.0b013e3283528a7c. Nucl Med Commun. 2012. PMID: 22422098 Review.
-
[Molecular neuroimaging in the study of cognitive impairment: contribution of the cerebral blood flow SPECT with 99mTc-HMPAO and 18F-FDG PET/CT scan].Rev Esp Med Nucl. 2011 Sep-Oct;30(5):301-6. doi: 10.1016/j.remn.2011.03.010. Epub 2011 Jun 2. Rev Esp Med Nucl. 2011. PMID: 21640440 Spanish.
-
Single photon emission computed tomography and positron emission tomography in cancer imaging.Cancer. 1991 Feb 15;67(4 Suppl):1261-70. doi: 10.1002/1097-0142(19910215)67:4+<1261::aid-cncr2820671524>3.0.co;2-l. Cancer. 1991. PMID: 1991287 Review.
Cited by
-
Chemical radioanalysis of production of positron-emitting radioisotope Gallium-68 via (p,n) and (p,2n) reactions using compact cyclotron for tomography applications.Heliyon. 2024 May 17;10(10):e31499. doi: 10.1016/j.heliyon.2024.e31499. eCollection 2024 May 30. Heliyon. 2024. PMID: 38813197 Free PMC article.
-
Bacterial imaging in tumour diagnosis.Microb Biotechnol. 2024 Jun;17(6):e14474. doi: 10.1111/1751-7915.14474. Microb Biotechnol. 2024. PMID: 38808743 Free PMC article. Review.
-
Impact of Fat Distribution and Metabolic Diseases on Cerebral Microcirculation: A Multimodal Study on Type 2 Diabetic and Obese Patients.J Clin Med. 2024 May 14;13(10):2900. doi: 10.3390/jcm13102900. J Clin Med. 2024. PMID: 38792441 Free PMC article.
-
Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy.Biomedicines. 2024 May 14;12(5):1088. doi: 10.3390/biomedicines12051088. Biomedicines. 2024. PMID: 38791050 Free PMC article. Review.
-
AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia.Theranostics. 2024 Apr 15;14(7):2656-2674. doi: 10.7150/thno.91456. eCollection 2024. Theranostics. 2024. PMID: 38773967 Free PMC article.
References
-
- Cuocolo A., Petretta M. PET and SPECT Specialty Grand Challenge. When Knowledge Travels at the Speed of Light, Photons Take to the Field. Front. Nucl. Med. 2021;1:671914. doi: 10.3389/fnume.2021.671914. - DOI
-
- Lee Y.S. Radiopharmaceuticals for Molecular Imaging. Open Nucl. Med. J. 2010;2:178–185. doi: 10.2174/1876388X01002010178. - DOI
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous