The emerging role of bacterial regulatory RNAs in disease
- PMID: 35379550
- DOI: 10.1016/j.tim.2022.03.007
The emerging role of bacterial regulatory RNAs in disease
Abstract
Pathogenic bacteria have evolved to sense their surrounding environments and regulate their gene expression to evade host immune defences and cause disease. RNA-mediated gene expression offers a fast and energy efficient alternative to conventional transcription factors. A myriad of regulatory RNAs have been identified, especially in pathogenic bacteria. However, whether these RNAs partake in disease remains largely unexplored. Here, we review current knowledge of regulatory RNAs in human-adapted upper respiratory tract pathogens. We propose that bacterial regulatory RNAs could play important roles in disease. Elucidating the function of regulatory RNAs and identifying polymorphisms among disease isolates would provide valuable insight into their pathogeneses. Finally, we discuss the outstanding issues of regulatory RNAs in research and their applications as drug targets, therapeutics, and in providing diagnostic information predictive of disease prognosis.
Keywords: Haemophilus influenzae; Neisseria meningitidis; Streptococcus pneumoniae; Streptococcus pyogenes; disease; regulatory RNA.
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of interests No interests are declared.
Similar articles
-
Regulation of bacterial gene expression by non-coding RNA: It is all about time!Cell Chem Biol. 2024 Jan 18;31(1):71-85. doi: 10.1016/j.chembiol.2023.12.011. Epub 2024 Jan 10. Cell Chem Biol. 2024. PMID: 38211587 Review.
-
Induction of Susceptibility to Disseminated Infection with IgA1 Protease-Producing Encapsulated Pathogens Streptococcus pneumoniae, Haemophilus influenzae Type b, and Neisseria meningitidis.mBio. 2022 Jun 28;13(3):e0055022. doi: 10.1128/mbio.00550-22. Epub 2022 Apr 14. mBio. 2022. PMID: 35420467 Free PMC article.
-
Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells.Elife. 2021 Feb 22;10:e64207. doi: 10.7554/eLife.64207. Elife. 2021. PMID: 33616037 Free PMC article.
-
The Small RNA ErsA Plays a Role in the Regulatory Network of Pseudomonas aeruginosa Pathogenicity in Airway Infections.mSphere. 2020 Oct 14;5(5):e00909-20. doi: 10.1128/mSphere.00909-20. mSphere. 2020. PMID: 33055260 Free PMC article.
-
RNA-mediated signal perception in pathogenic bacteria.Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1429. Epub 2017 Aug 9. Wiley Interdiscip Rev RNA. 2017. PMID: 28792118 Review.
Cited by
-
RNA cis-regulators are important for Streptococcus pneumoniae in vivo success.PLoS Genet. 2024 Mar 5;20(3):e1011188. doi: 10.1371/journal.pgen.1011188. eCollection 2024 Mar. PLoS Genet. 2024. PMID: 38442125 Free PMC article.
-
Agnodice: indexing experimentally supported bacterial sRNA-RNA interactions.mBio. 2024 Mar 13;15(3):e0301023. doi: 10.1128/mbio.03010-23. Epub 2024 Feb 6. mBio. 2024. PMID: 38319109 Free PMC article.
-
Non-coding RNAs in disease: from mechanisms to therapeutics.Nat Rev Genet. 2024 Mar;25(3):211-232. doi: 10.1038/s41576-023-00662-1. Epub 2023 Nov 15. Nat Rev Genet. 2024. PMID: 37968332 Review.
-
Neisseria meningitidis Sibling Small Regulatory RNAs Connect Metabolism with Colonization by Controlling Propionate Use.J Bacteriol. 2023 Mar 21;205(3):e0046222. doi: 10.1128/jb.00462-22. Epub 2023 Mar 1. J Bacteriol. 2023. PMID: 36856428 Free PMC article.
-
Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA.Genome Med. 2022 Dec 20;14(1):144. doi: 10.1186/s13073-022-01147-2. Genome Med. 2022. PMID: 36539881 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
