Sleep apnea and the risk of dementia: A systematic review and meta-analysis
- PMID: 35366021
- DOI: 10.1111/jsr.13589
Sleep apnea and the risk of dementia: A systematic review and meta-analysis
Abstract
Sleep apnea (SA) is potentially a modifiable risk factor for dementia. However, its associations to specific aetiologies of dementia remain uncertain. A systematic review and meta-analysis of cohort studies investigating the association between sleep apnea and specific aetiologies of dementia, including Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (LBD), vascular dementia (VaD), and frontotemporal dementia (FTD) was performed. The use of biomarkers to support clinical diagnoses in eligible studies was collected. Eleven studies were included, comprising 1,333,424 patients. Patients with sleep apnea had an increased risk of developing any type of neurocognitive disorder (HR: 1.43 [95% CI 1.26-1.62]), Alzheimer's disease (HR: 1.28 [95% CI 1.16-1.41]), and Parkinson's disease (HR: 1.54 [95% CI 1.30-1.84]). No statistically significant association was found for vascular dementia. One study reported a two-fold increased risk for Lewy body dementia (HR: 2.06 [95% CI 1.45-2.91]). No studies investigated the risk for frontotemporal dementia and none of the studies reported results pertaining to biomarkers. Sleep apnea is associated with a significantly increased risk of dementia, particularly for Alzheimer's disease and Parkinson's disease, but not for vascular dementia. Future studies should look at the impact of sleep apnea on specific dementia biomarkers.
Keywords: Alzheimer's disease; Lewy body dementia; biomarker; dementia; neurocognitive disorder; sleep apnea.
© 2022 European Sleep Research Society.
Similar articles
-
Chinese patients with Lewy body dementia had shorter survival and developed complications earlier than those with Alzheimer's disease.Singapore Med J. 2020 Oct;61(10):551-558. doi: 10.11622/smedj.2019103. Epub 2019 Sep 6. Singapore Med J. 2020. PMID: 31489427 Free PMC article.
-
The Association Between Somatic Symptom Disorders and Neurocognitive Disorders: A Systematic Review.Am J Geriatr Psychiatry. 2023 Jan;31(1):33-43. doi: 10.1016/j.jagp.2022.07.007. Epub 2022 Jul 24. Am J Geriatr Psychiatry. 2023. PMID: 35970734
-
[Guideline-based diagnosis of dementia etiology].Z Gerontol Geriatr. 2012 Dec;45(8):761-71; quiz 772-3. doi: 10.1007/s00391-012-0399-y. Z Gerontol Geriatr. 2012. PMID: 23184302 Review. German.
-
Comparisons of clinical symptoms in biomarker-confirmed Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia patients in a local memory clinic.Psychogeriatrics. 2015 Dec;15(4):235-41. doi: 10.1111/psyg.12103. Epub 2014 Dec 23. Psychogeriatrics. 2015. PMID: 25533477
-
Can clock drawing differentiate Alzheimer's disease from other dementias?Int Psychogeriatr. 2015 Oct;27(10):1649-60. doi: 10.1017/S1041610215000939. Epub 2015 Jul 3. Int Psychogeriatr. 2015. PMID: 26138809 Review.
Cited by
-
Cerebral perfusion is not impaired in persons with moderate obstructive sleep apnoea when awake.Sleep Breath. 2024 May 8. doi: 10.1007/s11325-024-03048-7. Online ahead of print. Sleep Breath. 2024. PMID: 38717716
-
Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol.BMJ Open. 2024 Apr 24;14(4):e082902. doi: 10.1136/bmjopen-2023-082902. BMJ Open. 2024. PMID: 38663922 Free PMC article.
-
Associations of sleep disorders with all-cause MCI/dementia and different types of dementia - clinical evidence, potential pathomechanisms and treatment options: A narrative review.Front Neurosci. 2024 Mar 22;18:1372326. doi: 10.3389/fnins.2024.1372326. eCollection 2024. Front Neurosci. 2024. PMID: 38586191 Free PMC article. Review.
-
Clinical Outcomes and Tau Pathology in Retired Football Players: Associations With Diagnosed and Witnessed Sleep Apnea.Neurol Clin Pract. 2024 Apr;14(2):e200263. doi: 10.1212/CPJ.0000000000200263. Epub 2024 Feb 26. Neurol Clin Pract. 2024. PMID: 38425491
-
Association Between Sleep Quantity and Quality in Early Adulthood With Cognitive Function in Midlife.Neurology. 2024 Jan 23;102(2):e208056. doi: 10.1212/WNL.0000000000208056. Epub 2024 Jan 3. Neurology. 2024. PMID: 38170947
References
REFERENCES
-
- Aarsland, D., Andersen, K., Larsen, J. P., Lolk, A., & Kragh-Sorensen, P. (2003). Prevalence and characteristics of dementia in Parkinson disease - an 8-year prospective study. Archives of Neurology, 60(3), 387-392. https://doi.org/10.1001/archneur.60.3.387
-
- Al-Qassabi, A., Fereshtehnejad, S. M., & Postuma, R. B. (2017). Sleep disturbances in the prodromal stage of Parkinson disease. Current Treatment Options in Neurology, 19(6), 22. https://doi.org/10.1007/s11940-017-0458-1
-
- Andre, C., Rehel, S., Kuhn, E., Landeau, B., Moulinet, I., Touron, E., Ourry, V., Le Du, G., Mezenger, F., Tomadesso, C., de Flores, R., Bejanin, A., Sherif, S., Delcroix, N., Manrique, A., Abbas, A., Marchant, N. L., Lutz, A., Klimecki, O. M., … Rauchs, G. (2020). Association of sleep-disordered breathing with Alzheimer disease biomarkers in community-dwelling older adults: A secondary analysis of a randomized clinical trial. JAMA Neurology, 77(6), 716-724. https://doi.org/10.1001/jamaneurol.2020.0311
-
- Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastiao, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., & Anderson, W. M. (2017). Sleep, cognitive impairment, and Alzheimer's disease: A systematic review and meta-analysis. Sleep, 40(1), 1-18. https://doi.org/10.1093/sleep/zsw032
-
- Bubu, O. M., Pirraglia, E., Andrade, A. G., Sharma, R. A., Gimenez-Badia, S., Umasabor-Bubu, O. Q., Hogan, M. M., Shim, A. M., Mukhtar, F., Sharma, N., Mbah, A. F., Seixas, A. A., Kam, K., Zizi, F., Borenstein, A. R., Mortimer, J. A., Kip, K. E., Morgan, D., Rosenzweig, I., … Varga Osorio, R. S. (2019). Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes. Sleep, 42(6), 1-13. https://doi.org/10.1093/sleep/zsz048
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical