Daytime napping and Alzheimer's dementia: A potential bidirectional relationship
- PMID: 35297533
- PMCID: PMC9481741
- DOI: 10.1002/alz.12636
Daytime napping and Alzheimer's dementia: A potential bidirectional relationship
Abstract
Introduction: Daytime napping is frequently seen in older adults. The longitudinal relationship between daytime napping and cognitive aging is unknown.
Methods: Using data from 1401 participants of the Rush Memory and Aging Project, we examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer's dementia during up to 14-year follow-up.
Results: Older adults tended to nap longer and more frequently with aging, while the progression of Alzheimer's dementia accelerates this change by more than doubling the annual increases in nap duration/frequency. Longer and more frequent daytime naps were associated with higher risk of Alzheimer's dementia. Interestingly, more excessive (longer or more frequent) daytime napping was correlated with worse cognition a year later, and conversely, worse cognition was correlated with more excessive naps a year later.
Discussion: Excessive daytime napping and Alzheimer's dementia may possess a bidirectional relationship or share common pathophysiological mechanisms.
Keywords: actigraphy; aging; cognitive aging; cohort study; longitudinal association; sleep.
© 2022 the Alzheimer's Association.
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Comment in
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A Mendelian randomization study of Alzheimer's disease and daytime napping.Alzheimers Dement. 2024 Jan;20(1):741-742. doi: 10.1002/alz.13505. Epub 2023 Oct 12. Alzheimers Dement. 2024. PMID: 37828703 Free PMC article. No abstract available.
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