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Review
. 2022 Feb:153:105275.
doi: 10.1016/j.neuint.2021.105275. Epub 2022 Jan 3.

MDMA related neuro-inflammation and adenosine receptors

Fatemeh Kermanian  1 , Masoumeh Seghatoleslam  2 , Simin Mahakizadeh  3
Affiliations
Review

MDMA related neuro-inflammation and adenosine receptors

Fatemeh Kermanian et al. Neurochem Int. 2022 Feb.

Abstract

3,4-methylenedioxymethamphetamine (MDMA) is a world-wide abused psychostimulant, which has the neurotoxic effects on dopaminergic and serotonergic neurons in both rodents and non-human primates. Adenosine acts as a neurotransmitter in the brain through the activation of four specific G-protein-coupled receptors and it acts as a neuromodulator of dopamine neurotransmission. Recent studies suggest that stimulation of adenosine receptors oppose many behavioral effects of methamphetamines. This review summarizes the specific cellular mechanisms involved in MDMA neuroinflammatory effects, along with the protective effects of adenosine receptors.

Keywords: Adenosine receptors; Ecstasy; MDMA; Neuroinflammation.

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