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. 2022 Aug;279(8):4069-4075.
doi: 10.1007/s00405-021-07242-1. Epub 2022 Jan 5.

Quality of life in head and neck cancer patients at 5 years after free flap reconstruction: a significant decline during the follow-up

Sanna Lahtinen  1   2 , Krisztina Molnár #  1   2 , Siiri Hietanen #  2 , Petri Koivunen  3   4 , Pasi Ohtonen  2   5 , Antti Alakärppä  3   4 , Janne Liisanantti  6   7
Affiliations

Quality of life in head and neck cancer patients at 5 years after free flap reconstruction: a significant decline during the follow-up

Sanna Lahtinen et al. Eur Arch Otorhinolaryngol. 2022 Aug.

Abstract

Purpose: Free flap reconstructions following head and neck tumor resection are known to involve more than 50% rate of complications and other adverse events and up to 50% mortality during a 5-year follow-up. We aimed to examine the difference in the long-term quality of life (QoL) between the 2-year and 5-year assessments after free flap surgery for cancer of the head and neck.

Methods: A total of 28 of the 39 eligible patients responded to the survey. QoL was assessed at 5 years after operation and compared with the assessment performed at 2 years after the operation using RAND-36, EORTC-C30 and H&N-35, and SWAL-QOL tools.

Results: The criteria for poor QoL using RAND-36 tool was met in 11 (39.3%) patients in contrast to 4 (14.3%, P = 0.003) patients in the 2-year assessment. EORTC-C30 global score was decreased from 83.9 (SD16.4) to 64.6 (SD 24.0, P < 0.001) during the follow-up. In both RAND-36 and EORTC-C30 surveys, decline was found in physical and role functioning together with energy and emotional well-being domains. SWAL-QOL showed poor swallowing-related QoL in both assessments.

Conclusion: We found a significant decline in QoL during a 5-year follow-up after free flap surgery for cancer of the head and neck.

Keywords: Cancer of the head and neck; Free flap surgery; Long-term follow-up; Quality of life.

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Conflict of interest statement

None of the authors report conflict of interest.

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References

    1. McMahon JD, MacIver C, Smith M, et al. Postoperative complications after major head and neck surgery with free flap repair—prevalence, patterns, and determinants: a prospective cohort study. Br J Oral Maxillofac Surg. 2013;51:689–695. doi: 10.1016/j.bjoms.2013.04.015. - DOI - PubMed
    1. Lahtinen S, Koivunen P, Ala-Kokko T, et al. Complications and outcome after free flap surgery for cancer of the head and neck. Br J Oral Maxillofac Surg. 2018;56:684–691. doi: 10.1016/j.bjoms.2018.07.009. - DOI - PubMed
    1. Lahtinen S, Koivunen P, Ala-Kokko T, et al. Quality of life after free flap surgery for cancer of the head and neck in patients with or without postoperative complications. Eur Arch Otorhinolaryngol. 2018;275:2575–2584. doi: 10.1007/s00405-018-5103-4. - DOI - PubMed
    1. Borggreven PA, Aaronson NK, Verdonck-de Leeuw IM, et al. Quality of life after surgical treatment for oral and oropharyngeal cancer: a prospective longitudinal assessment of patients reconstructed by a microvascular flap. Oral Oncol. 2006;43:1034–1042. doi: 10.1016/j.oraloncology.2006.11.017. - DOI - PubMed
    1. Bozec A, Poissonnet G, Chamorey E, et al. Free-flap head and neck reconstruction and quality of life: a 2-year prospective study. Laryngoscope. 2008;118:874–880. doi: 10.1097/MLG.0b013e3181644abd. - DOI - PubMed