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Editorial
. 2021 Nov 25:9:799268.
doi: 10.3389/fcell.2021.799268. eCollection 2021.

Editorial: Hair Follicle Stem Cell Regeneration in Aging

Mingxing Lei  1   2 , Sung-Jan Lin  3   4 , Cheng-Ming Chuong  5
Affiliations
Editorial

Editorial: Hair Follicle Stem Cell Regeneration in Aging

Mingxing Lei et al. Front Cell Dev Biol. .
No abstract available

Keywords: aging; hair regeneration; niche; skin organoid; wound-induced hair neogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Hair follicle stem cell regeneration in aging. Hair follicle undergoes cyclic renewal, which is regulated by cyclic activation of quiescent stem cells controlled by a core circuit involving beta-catenin. This core molecular circuit involves interactions between hair follicle stem cell (HFSC) and dermal papilla within the hair follicle. Adjacent to the follicles, blood vessels, nerves, arrector pili muscle, intradermal adipose tissues, etc. form a larger niche that also can affect HFSC activation. Further, outside environment can also modulate the cyclic renewal behavior of hair follicles. The effects of these modulators change during aging. The telogen phase of the hair cycle becomes dominant during aging, leading to decreased hair regeneration. Aged cells can be reactivated to regenerate hair follicles under wound-induced hair neogenesis condition or using several 2D or 3D culture models. APM, arrector pili muscle; DP, dermal papilla; HFSC, hair follicle stem cells; HG, hair germ; SG, sebaceous gland; SN, sympathetic nerve.
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