Conflict of Interest Disclosures: Dr Cohen has received research grant support and consulting fees from Edwards Lifesciences, Medtronic, Abbott, and Boston Scientific outside the submitted work. Dr Baron has served on an advisory board for Boston Scientific Corporation and Abiomed, has received grant support from Boston Scientific Corporation and Abiomed, and has been a consultant for Abbott, Abiomed, Edwards Lifesciences, and MitraLabs outside the submitted work. Dr Desai reports speaker and consultant fees from Gore, Medtronic, and Terumo and grants from Gore and Medtronic outside the submitted work. Dr Szeto reports investigator and advisory board fees from Edwards Lifesciences and Medtronic. Dr Herrmann reports institutional research funding from Abbott Vascular, Boston Scientific, Edwards Lifesciences, and Medtronic and consulting fees and honoraria from Edwards Lifesciences and Medtronic during the conduct of the study, as well as grants from Ancora, Shockwave, and Gore and equity from Holistick Medical and Microinterventional Devices outside the submitted work. Dr Giri has served on an advisory board for AstraZeneca and received research support to the institution from Recor Medical and St. Jude Medical; Dr Giri also reported personal fees from Boston Scientific, Inari Medical, AstraZeneca, and Philips Medical and grants from Boston Scientific and Inari Medical outside the submitted work. Dr Fanaroff receives research support from the American Heart Association and Boston Scientific and honoraria from the American Heart Association outside the submitted work. Dr Khatana reported grants from National Heart, Lung, and Blood Institute (grant 1K23HL153772-01) and American Heart Association (grant 20CDA35320251) during the conduct of the study. Dr Vemulapalli reported grants from American College of Cardiology, Society of Thoracic Surgeons, Abbott Vascular, and Boston Scientific outside the submitted work; and grants or contracts from the US Food and Drug Administration (Nest CC); National Institutes of Health (R01 and Small Business Innovation Research) and Cytokinetics; consulting and advisory board involvement with Boston Scientific, Janssen, HeartFlow, and the American College of Physicians. Dr Nallamothu reported being a principal investigator or coinvestigator on research grants from the National Institutes of Health, Veterans Administration Health Science Research and Development, the American Heart Association, Apple, Toyota, and Janssen. Dr Nallamothu also receives compensation as editor-in-chief of Circulation: Cardiovascular Quality & Outcomes, a journal of the American Heart Association, and is a coinventor on US utility patent US 9,962,124 as well as a provisional patent application (54423), which both use software technology with signal processing and machine learning to automate the reading of coronary angiograms and are held by the University of Michigan and licensed to AngioInsight Inc, in which he holds ownership shares and receives consultancy fees. The University of Michigan also has filed patents on Dr Nallamothu’s behalf on the use of computer vision for imaging applications in gastroenterology, with technology elements licensed to Applied Morphomics Inc, in which he has no relationship or stake. No other disclosures were reported.