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. 2022 Jan:184:111179.
doi: 10.1016/j.paid.2021.111179. Epub 2021 Aug 20.

Exploring the Links between Personality and Immune Function

Summer Mengelkoch  1 , Jeff Gassen  1 , Emily K Corrigan  1 , Sarah E Hill  1
Affiliations

Exploring the Links between Personality and Immune Function

Summer Mengelkoch et al. Pers Individ Dif. 2022 Jan.

Abstract

Decades of research finds associations between personality traits and health. In recent years, it has become clear that the activities of the immune system play a key role in linking these variables. In the current work, we add to this research by exploring the relationship between Big Five personality traits and (Study 1) polymorphisms known to impact cytokine release and (Study 2) immunological parameters measured in vivo (differential white blood cell counts, plasma proinflammatory cytokine levels) and in vitro (proinflammatory cytokine release by peripheral blood mononuclear cells, Staphylococcus aureus growth in plasma). Results provide insights into potential mechanistic drivers of the link between personality and immune function and the possibility that, in some cases, relationships between personality and immune function may be sex differentiated.

Keywords: agreeableness; conscientiousness; cytokines; extraversion; inflammation; neuroticism; openness to experience; personality.

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References

    1. Allen MS, & Laborde S (2017). Five factor personality traits and inflammatory biomarkers in applications. Journal of Personality, 60(2), 175–215.
    1. Allen MS, Magee CA, Vella SA, & Laborde S (2017). Bidirectional associations between personality and physical activity in adulthood. Health Psychology, 36(4), 332. - PubMed
    1. Amim LH, Pacheco AG, Fonseca-Costa J, Loredo CS, Rabahi MF, Melo MH, ..., Santos AD (2008). Role of IFN-γ+ 874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects. Molecular Biology Reports, 35(4), 563–566. - PubMed
    1. Amoroso CR, & Nunn CL (2021). Epidemiological transitions in human evolution and the richness of viruses, helminths, and protozoa. Evolution, Medicine, and Public Health, 9(1), 139–148. - PMC - PubMed
    1. Armon G, Melamed S, Shirom A, Berliner S, & Shapira I (2013). The associations of the Five Factor Model of personality with inflammatory biomarkers: A four-year prospective study. Personality and Individual Differences, 54(6), 750–755.

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