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Review
. 2022 May-Jun;44(3):342-348.
doi: 10.1590/1516-4446-2021-2156.

Melatonin use during pregnancy and lactation: A scoping review of human studies

Tya Vine  1 , Gregory M Brown  2   3 , Benicio N Frey  4   5
Affiliations
Review

Melatonin use during pregnancy and lactation: A scoping review of human studies

Tya Vine et al. Braz J Psychiatry. 2022 May-Jun.

Abstract

Objective: The prevalence of sleep disorders during the perinatal period is high and large health administrative database surveys have shown that the use of exogenous melatonin in pregnant populations is quite common, about 4%. Much of the concern about using melatonin during pregnancy and breastfeeding stems from animal research. Thus, the objective of this article is to provide a critical review of human studies related to exogenous melatonin use during pregnancy and breastfeeding.

Methods: The electronic databases Ovid, MEDLINE, Embase, and the Cochrane Library were searched using terms and keywords related to melatonin, pregnancy, and breastfeeding.

Results: Fifteen studies were included in this review. Eight focused on melatonin use during pregnancy and seven focused on melatonin use during breastfeeding. There was a variety of study designs, including case reports, cohort studies, and clinical trials. There is a lack of randomized, controlled trials examining the efficacy and safety of melatonin as a treatment for sleep disorders during pregnancy or breastfeeding and, notably, insomnia was not the primary outcome measure in any of the studies included in this review. Clinical trials that used exogenous melatonin during pregnancy and breastfeeding for other clinical conditions have not suggested major safety concerns or adverse events.

Conclusion: Contrary to what animal studies have suggested, evidence from clinical studies to date suggests that melatonin use during pregnancy and breastfeeding is probably safe in humans. This review further emphasizes the need for clinical studies on sleep disorders, including exogenous melatonin, during pregnancy and lactation.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. Flowchart of review methodology.
See this image and copyright information in PMC

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References

    1. Schweiger MS. Sleep disturbance in pregnancy. A subjective survey. Am J Obstet Gynecol. 1972;114:879–82. - PubMed
    1. Suzuki S, DennersteinL, Greenwood KM, Armstrong SM, Satohisa E. Sleeping patterns during pregnancy in Japanese women. J Psychosom Obstet Gynaecol. 1994;15:19–26. - PubMed
    1. Hayase M, Shimada M, Seki H. Sleep quality and stress in women with pregnancy-induced hypertension and gestational diabetes mellitus. Women Birth. 2014;27:190–5. - PubMed
    1. Warland J, Dorrian J, Morrison JL, O’Brien LM. Maternal sleep during pregnancy and poor fetal outcomes: a scoping review of the literature with meta-analysis. Sleep Med Rev. 2018;41:197–219. - PubMed
    1. Palagini L, Gemignani A, Banti S, Manconi M, Mauri M, Riemann D. Chronic sleep loss during pregnancy as a determinant of stress: impact on pregnancy outcome. Sleep Med. 2014;15:853–9. - PubMed