19 F MRI Probes for Multimodal Imaging
- PMID: 34705306
- DOI: 10.1002/chem.202102556
19 F MRI Probes for Multimodal Imaging
Abstract
Magnetic resonance imaging (MRI) is one of the most powerful imaging tools today, capable of displaying superior soft-tissue contrast. This review discusses developments in the field of 19 F MRI multimodal probes in combination with optical fluorescence imaging (OFI), 1 H MRI, chemical exchange saturation transfer (CEST) MRI, ultrasonography (USG), X-ray computed tomography (CT), single photon emission tomography (SPECT), positron emission tomography (PET), and photoacoustic imaging (PAI). In each case, multimodal 19 F MRI probes compensate for the deficiency of individual techniques and offer improved sensitivity or accuracy of detection over unimodal counterparts. Strategies for designing 19 F MRI multimodal probes are described with respect to their structure, physicochemical properties, biocompatibility, and the quality of images.
Keywords: 19F MRI; contrast agents; medicinal chemistry; multimodal imaging; sensors.
© 2021 Wiley-VCH GmbH.
Similar articles
-
PET-MR and SPECT-MR multimodality probes: Development and challenges.Theranostics. 2018 Nov 29;8(22):6210-6232. doi: 10.7150/thno.26610. eCollection 2018. Theranostics. 2018. PMID: 30613293 Free PMC article. Review.
-
Recent developments in multimodality fluorescence imaging probes.Acta Pharm Sin B. 2018 May;8(3):320-338. doi: 10.1016/j.apsb.2018.03.010. Epub 2018 Mar 30. Acta Pharm Sin B. 2018. PMID: 29881672 Free PMC article. Review.
-
Comprehensive Oncologic Imaging in Infants and Preschool Children With Substantially Reduced Radiation Exposure Using Combined Simultaneous ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging: A Direct Comparison to ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.Invest Radiol. 2016 Jan;51(1):7-14. doi: 10.1097/RLI.0000000000000200. Invest Radiol. 2016. PMID: 26309185
-
Positron Emission Tomography/Magnetic Resonance Imaging for Local Tumor Staging in Patients With Primary Breast Cancer: A Comparison With Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging.Invest Radiol. 2015 Aug;50(8):505-13. doi: 10.1097/RLI.0000000000000197. Invest Radiol. 2015. PMID: 26115367
-
Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology.Acc Chem Res. 2008 Dec;41(12):1630-40. doi: 10.1021/ar800045c. Acc Chem Res. 2008. PMID: 18698851
Cited by
-
How to 19F MRI: applications, technique, and getting started.BJR Open. 2023 Sep 29;5(1):20230019. doi: 10.1259/bjro.20230019. eCollection 2023. BJR Open. 2023. PMID: 37953866 Free PMC article. Review.
-
Fluorinated hydrogel nanoparticles with regulable fluorine contents and T2 relaxation times as 19F MRI contrast agents.RSC Adv. 2023 Jul 25;13(32):22335-22345. doi: 10.1039/d3ra02827e. eCollection 2023 Jul 19. RSC Adv. 2023. PMID: 37497094 Free PMC article.
-
Hydrazone Molecular Switches with Paramagnetic Center as 19F Magnetic Resonance Imaging Relaxation Enhancement Agents for pH Imaging.ACS Sens. 2023 May 26;8(5):1971-1979. doi: 10.1021/acssensors.3c00080. Epub 2023 May 17. ACS Sens. 2023. PMID: 37198734 Free PMC article.
-
Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe.Molecules. 2023 Feb 10;28(4):1695. doi: 10.3390/molecules28041695. Molecules. 2023. PMID: 36838682 Free PMC article.
-
Tuning the pH of Activation of Fluorinated Hydrazone-Based Switches─A Pathway to Versatile 19F Magnetic Resonance Imaging Contrast Agents.ACS Sens. 2023 Feb 24;8(2):721-727. doi: 10.1021/acssensors.2c02251. Epub 2023 Jan 25. ACS Sens. 2023. PMID: 36695323 Free PMC article.
References
-
- R. Weissleder, M. J. Pittet, Nature 2008, 452, 580.
-
- H. Kobayashi, M. R. Longmire, M. Ogawa, P. L. Choyke, Chem. Soc. Rev. 2011, 40, 4626.
-
- L. Martí-Bonmatí, R. Sopena, P. Bartumeus, P. Sopena, Contrast Media Mol. Imaging 2010, 5, 180.
-
- R. Kumar, P. Gautam, Ritambhara, S. Vijayaraghavalu, G. C. Shukla, M. Kumar, Clin. Epidemiol. Glob. Heal. 2020, 8, 1119.
-
- R. Pujales-Paradela, T. Savić, D. Esteban-Gómez, G. Angelovski, F. Carniato, M. Botta, C. Platas-Iglesias, R. Pujales-Paradela, T. Savić, D. Esteban-Gómez, G. Angelovski, F. Carniato, M. Botta, C. Platas-Iglesias, Chem. A Eur. J. 2019, 25, 4782.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources