Comment

. 2021 Oct;27(10):1687-1688.

doi: 10.1038/s41591-021-01524-1. Epub 2021 Oct 11.

Caution at psychiatry's psychedelic frontier

Matthew J Burke^{1

2

3

4}, Daniel M Blumberger^{5

6}

Affiliations

¹ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. matt.burke@utoronto.ca.
² Division of Neurology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. matt.burke@utoronto.ca.
³ Harquail Centre for Neuromodulation and Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada. matt.burke@utoronto.ca.
⁴ Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. matt.burke@utoronto.ca.
⁵ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
⁶ Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada.

PMID: 34635858
DOI: 10.1038/s41591-021-01524-1

Comment

Caution at psychiatry's psychedelic frontier

Matthew J Burke et al. Nat Med. 2021 Oct.

. 2021 Oct;27(10):1687-1688.

doi: 10.1038/s41591-021-01524-1. Epub 2021 Oct 11.

Authors

Matthew J Burke^{1

2

3

4}, Daniel M Blumberger^{5

6}

Affiliations

¹ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. matt.burke@utoronto.ca.
² Division of Neurology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. matt.burke@utoronto.ca.
³ Harquail Centre for Neuromodulation and Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Canada. matt.burke@utoronto.ca.
⁴ Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. matt.burke@utoronto.ca.
⁵ Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
⁶ Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Canada.

PMID: 34635858
DOI: 10.1038/s41591-021-01524-1

No abstract available

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Comment in

Reply to: Caution at psychiatry's psychedelic frontier and Challenges with benchmarking of MDMA-assisted psychotherapy.
Mitchell J, Coker A, Yazar-Klosinski B. Mitchell J, et al. Nat Med. 2021 Oct;27(10):1691-1692. doi: 10.1038/s41591-021-01526-z. Epub 2021 Oct 11. Nat Med. 2021. PMID: 34635856 No abstract available.

Comment on

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study.
Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, Ot'alora G M, Garas W, Paleos C, Gorman I, Nicholas C, Mithoefer M, Carlin S, Poulter B, Mithoefer A, Quevedo S, Wells G, Klaire SS, van der Kolk B, Tzarfaty K, Amiaz R, Worthy R, Shannon S, Woolley JD, Marta C, Gelfand Y, Hapke E, Amar S, Wallach Y, Brown R, Hamilton S, Wang JB, Coker A, Matthews R, de Boer A, Yazar-Klosinski B, Emerson A, Doblin R. Mitchell JM, et al. Nat Med. 2021 Jun;27(6):1025-1033. doi: 10.1038/s41591-021-01336-3. Epub 2021 May 10. Nat Med. 2021. PMID: 33972795 Free PMC article. Clinical Trial.

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The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.
Zaretsky TG, Jagodnik KM, Barsic R, Antonio JH, Bonanno PA, MacLeod C, Pierce C, Carney H, Morrison MT, Saylor C, Danias G, Lepow L, Yehuda R. Zaretsky TG, et al. Curr Neuropharmacol. 2024;22(4):636-735. doi: 10.2174/1570159X22666231027111147. Curr Neuropharmacol. 2024. PMID: 38284341 Free PMC article. Review.
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Beans C. Beans C. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2321906121. doi: 10.1073/pnas.2321906121. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170743 Free PMC article. No abstract available.
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Husain MI, Blumberger DM, Castle DJ, Ledwos N, Fellows E, Jones BDM, Ortiz A, Kloiber S, Wang W, Rosenblat JD, Mulsant BH. Husain MI, et al. BJPsych Open. 2023 Jul 25;9(4):e134. doi: 10.1192/bjo.2023.535. BJPsych Open. 2023. PMID: 37489299 Free PMC article.
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Heifets BD, Olson DE. Heifets BD, et al. Neuropsychopharmacology. 2024 Jan;49(1):104-118. doi: 10.1038/s41386-023-01666-5. Epub 2023 Jul 24. Neuropsychopharmacology. 2024. PMID: 37488282 Review.

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References

1. Mitchell, J. M. et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat. Med. https://doi.org/10.1038/s41591-021-01336-3 (2021).
1. Colloca, L. & Barsky, A. J. Placebo and nocebo effects. N. Engl. J. Med. 382, 554–561 (2020). 6. - DOI
1. Ashar, Y. K., Chang, L. J. & Wager, T. D. Brain mechanisms of the placebo effect: an affective appraisal account. Annu Rev. Clin. Psychol. 13, 73–98 (2017). - DOI
1. Burke, M. J., Kaptchuk, T. J. & Pascual-Leone, A. Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation. Ann. Neurol. 85, 12–20 (2019). - DOI
1. Feder, A. et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71, 681–688 (2014). - DOI

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