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Review
. 2021 Nov;66(6):740-748.
doi: 10.1111/jmwh.13283. Epub 2021 Sep 12.

Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment

Jessica A Pettigrew  1 , Andrew M Novick  2
Affiliations
Review

Hypoactive Sexual Desire Disorder in Women: Physiology, Assessment, Diagnosis, and Treatment

Jessica A Pettigrew et al. J Midwifery Womens Health. 2021 Nov.

Abstract

Nearly half of women in the United States report problems with sexual function. Many health care providers do not ask about sexual concerns during routine clinical encounters because of personal discomfort, lack of familiarity with treatment, or the belief that they lack adequate time to address this complex issue. This may be especially true for hypoactive sexual desire disorder (HSDD), the most commonly identified sexual problem among women. HSDD is characterized by a deficiency of sexual thoughts, feelings, or receptiveness to sexual stimulation that has been present for at least 6 months, causes personal distress, and is not due to another medical condition. This is an up-to-date overview of HSDD for clinicians, discussing its physiology, assessment, diagnosis, and treatment strategies. Although a definitive physiology of HSDD is still unknown, multiple hormones and neurotransmitters likely participate in a dual-control model to balance excitation and inhibition of sexual desire. For assessment and diagnosis, validated screening tools are discussed, and the importance of a biopsychosocial assessment is emphasized, with guidance on how this can be implemented in clinical encounters. The 2 recently approved medications for HSDD, flibanserin and bremelanotide, are reviewed as well as off-label treatments. Overall, HSDD represents a common yet likely underrecognized disorder that midwives and other health care providers who care for women across the life span are in a unique position to address.

Keywords: hypoactive sexual desire disorder; libido; sexual desire; sexual dysfunction; women's health.

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Conflict of interest statement

Conflict of Interest: The authors have no relevant conflicts of interests to disclose.

Figures

Figure 1.
Figure 1.
Various physiological substrates and their role in either exciting or inhibiting sexual desire, based on the Dual-Control Model (Bancroft et al, 2009). Deficient excitation, excessive inhibition, or a mix of both can contribute to the physiology of hypoactive sexual desire disorder. aSerotonin and progesterone have both excitatory and inhibitory properties, though are usually considered inhibitory. α-MSH (alpha-melanocyte stimulating hormone).
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