Dual role of microRNA-1297 in the suppression and progression of human malignancies
- PMID: 34243098
- DOI: 10.1016/j.biopha.2021.111863
Dual role of microRNA-1297 in the suppression and progression of human malignancies
Abstract
MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded and tiny RNAs that modulate several biological functions, more importantly, the pathophysiology of numerous human cancers. They are bound with target mRNAs and thereby regulate gene expression at post-transcriptional levels. MiRNAs can either trigger cancer progression as an oncogene or alleviate it as a tumor suppressor. Abnormal expression of microRNA-1297 (miR-1297) has been noticed in several human cancers suggesting a distinct role for the miRNA in tumorigenesis. More specifically, it is both up-regulated and down-regulated in various cancers suggesting that it can act as both tumor suppressor and oncogene. This review systematically highlights the different roles of miR-1297 in the pathophysiology of human cancers, explains the mechanisms underlying miR-1297-mediated tumorigenesis, and discusses its potential prognostic, diagnostic, and therapeutic importance.
Keywords: Cancer; MicroRNA-1297; Oncogene; Tumor suppressor.
Copyright © 2021. Published by Elsevier Masson SAS.
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