COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation
- PMID: 34218318
- PMCID: PMC8254625
- DOI: 10.1007/s00431-021-04191-z
COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation
Abstract
The study aims to present the incidence of COVID-19 in pediatric patients undergoing renal replacement therapy (RRT) and to compare the severity and outcomes of the disease between the dialysis and kidney transplant (KTx) groups. This multicenter observational study was conducted between 1 April and 31 December 2020 in Istanbul. Members of the Istanbul branch of the Turkish Pediatric Nephrology Association were asked to report all confirmed cases of COVID-19 who were on RRT, as well as the number of prevalent RRT patients under the age of 20. A total of 46 confirmed cases of COVID-19 were reported from 12 centers, of which 17 were dialysis patients, and 29 were KTx recipients. Thus, the incidence rate of COVID-19 was 9.3% among dialysis patients and 9.2% among KTx recipients over a 9-month period in Istanbul. Twelve KTx recipients and three dialysis patients were asymptomatic (p = 0.12). Most of the symptomatic patients in both the dialysis and KTx groups had a mild respiratory illness. Only two patients, one in each group, experienced a severe disease course, and only one hemodialysis patient had a critical illness that required mechanical ventilation. In the entire cohort, one hemodialysis patient with multiple comorbidities died.Conclusion: While most cases are asymptomatic or have a mild disease course, pediatric patients undergoing dialysis and a kidney transplant are at increased risk for COVID-19. What is Known: • In adult population, both dialysis patients and kidney transplant recipients are at increased risk for severe illness of COVID-19 and have higher mortality rate. • Children with kidney transplantation are not at increased risk for COVID-19 and most have mild disease course. • Data on children on dialysis are scarce. What is New: • Pediatric patients undergoing dialysis and kidney transplantation have an increased risk for COVID-19. • Most patients undergoing renal replacement therapy either on dialysis or transplanted develop asymptomatic or mild COVID-19 disease with a favorable outcome.
Keywords: COVID-19; Children; Dialysis; Kidney transplantation; Pediatric; RRT; Renal replacement therapy.
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Conflict of interest statement
The authors declare no competing interests.
Figures
Similar articles
-
[REIN Report 2011--summary].Nephrol Ther. 2013 Sep;9 Suppl 1:S3-6. doi: 10.1016/S1769-7255(13)70036-1. Nephrol Ther. 2013. PMID: 24119584 French.
-
Time on previous renal replacement therapy is associated with worse outcomes of COVID-19 in a regional cohort of kidney transplant and dialysis patients.Medicine (Baltimore). 2021 Mar 12;100(10):e24893. doi: 10.1097/MD.0000000000024893. Medicine (Baltimore). 2021. PMID: 33725847 Free PMC article.
-
Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology.J Nephrol. 2020 Aug;33(4):725-736. doi: 10.1007/s40620-020-00794-1. Epub 2020 Jul 3. J Nephrol. 2020. PMID: 32621109 Free PMC article.
-
Comparison of life participation activities among adults treated by hemodialysis, peritoneal dialysis, and kidney transplantation: a systematic review.Am J Kidney Dis. 2013 Nov;62(5):953-73. doi: 10.1053/j.ajkd.2013.03.022. Epub 2013 May 29. Am J Kidney Dis. 2013. PMID: 23725972 Free PMC article. Review.
-
Nephrology, dialysis and transplantation in Turkey.Nephrol Dial Transplant. 2002 Dec;17(12):2087-93. doi: 10.1093/ndt/17.12.2087. Nephrol Dial Transplant. 2002. PMID: 12454217 Review.
Cited by
-
COVID-19 disease among children and young adults enrolled in the North American Pediatric Renal Trials and Collaborative Studies registry.Pediatr Nephrol. 2024 May;39(5):1459-1468. doi: 10.1007/s00467-023-06241-0. Epub 2023 Dec 11. Pediatr Nephrol. 2024. PMID: 38082091
-
Acute kidney injury in children with moderate-severe COVID-19 and multisystem inflammatory syndrome in children: a referral center experience.Pediatr Nephrol. 2024 Mar;39(3):867-877. doi: 10.1007/s00467-023-06125-3. Epub 2023 Sep 7. Pediatr Nephrol. 2024. PMID: 37676500
-
Reduced Humoral and Cellular Immune Response to Primary COVID-19 mRNA Vaccination in Kidney Transplanted Children Aged 5-11 Years.Viruses. 2023 Jul 14;15(7):1553. doi: 10.3390/v15071553. Viruses. 2023. PMID: 37515239 Free PMC article.
-
Immunologic Response to SARS-CoV-2 Vaccination in Pediatric Kidney Transplant Recipients: A Systematic Review and Meta-Analysis.Vaccines (Basel). 2023 Jun 9;11(6):1080. doi: 10.3390/vaccines11061080. Vaccines (Basel). 2023. PMID: 37376469 Free PMC article. Review.
-
COVID-19 in immunocompromised children and adolescents.Clin Exp Pediatr. 2023 May;66(5):182-189. doi: 10.3345/cep.2022.00878. Epub 2023 Apr 18. Clin Exp Pediatr. 2023. PMID: 37070297 Free PMC article.
References
-
- WHO Coronavirus Disease (COVID-19) Dashboard. Available at: https://covid19.who.int/covid-19-data.page. Accessed June 11, 2021
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous