Decoding mechanical cues by molecular mechanotransduction
- PMID: 34218181
- DOI: 10.1016/j.ceb.2021.05.006
Decoding mechanical cues by molecular mechanotransduction
Abstract
Cells are exposed to a variety of mechanical cues, including forces from their local environment and physical properties of the tissue. These mechanical cues regulate a vast number of cellular processes, relying on a repertoire of mechanosensors that transduce forces into biochemical pathways through mechanotransduction. Forces can act on different parts of the cell, carry information regarding magnitude and direction, and have distinct temporal profiles. Thus, the specific cellular response to mechanical forces is dependent on the ability of cells to sense and transduce these physical parameters. In this review, we will highlight recent findings that provide insights into the mechanisms by which different mechanosensors decode mechanical cues and how their coordinated response determines the cellular outcomes.
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Conflict of interest statement Nothing declared.
Similar articles
-
Cell response to mechanical microenvironment cues via Rho signaling: From mechanobiology to mechanomedicine.Acta Biomater. 2023 Mar 15;159:1-20. doi: 10.1016/j.actbio.2023.01.039. Epub 2023 Jan 28. Acta Biomater. 2023. PMID: 36717048 Review.
-
Control of cellular responses to mechanical cues through YAP/TAZ regulation.J Biol Chem. 2019 Nov 15;294(46):17693-17706. doi: 10.1074/jbc.REV119.007963. Epub 2019 Oct 8. J Biol Chem. 2019. PMID: 31594864 Free PMC article. Review.
-
Mechanotransduction in tissue engineering: Insights into the interaction of stem cells with biomechanical cues.Exp Cell Res. 2023 Oct 15;431(2):113766. doi: 10.1016/j.yexcr.2023.113766. Epub 2023 Sep 7. Exp Cell Res. 2023. PMID: 37678504 Review.
-
Preparation of hydroxy-PAAm hydrogels for decoupling the effects of mechanotransduction cues.J Vis Exp. 2014 Aug 28;(90):51010. doi: 10.3791/51010. J Vis Exp. 2014. PMID: 25225964 Free PMC article.
-
Cells under pressure: how yeast cells respond to mechanical forces.Trends Microbiol. 2022 May;30(5):495-510. doi: 10.1016/j.tim.2021.11.006. Epub 2022 Jan 6. Trends Microbiol. 2022. PMID: 35000797 Review.
Cited by
-
The Cytoskeleton and Its Binding Proteins as Mechanosensors, Transducers, and Functional Regulators of Cells.Int J Mol Sci. 2023 Dec 22;25(1):172. doi: 10.3390/ijms25010172. Int J Mol Sci. 2023. PMID: 38203343 Free PMC article.
-
Uniaxial Cyclic Cell Stretching Device for Accelerating Cellular Studies.Micromachines (Basel). 2023 Jul 31;14(8):1537. doi: 10.3390/mi14081537. Micromachines (Basel). 2023. PMID: 37630073 Free PMC article.
-
Extracellular matrix sensing via modulation of orientational order of integrins and F-actin in focal adhesions.Life Sci Alliance. 2023 Jul 18;6(10):e202301898. doi: 10.26508/lsa.202301898. Print 2023 Oct. Life Sci Alliance. 2023. PMID: 37463754 Free PMC article.
-
Cyclic Stretch-Induced Mechanical Stress Applied at 1 Hz Frequency Can Alter the Metastatic Potential Properties of SAOS-2 Osteosarcoma Cells.Int J Mol Sci. 2023 Apr 22;24(9):7686. doi: 10.3390/ijms24097686. Int J Mol Sci. 2023. PMID: 37175397 Free PMC article.
-
Dynamic mechanobiology of cardiac cells and tissues: Current status and future perspective.Biophys Rev (Melville). 2023 Mar;4(1):011314. doi: 10.1063/5.0141269. Epub 2023 Mar 29. Biophys Rev (Melville). 2023. PMID: 37008887 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
