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Review
. 2021 Aug 15:782:146855.
doi: 10.1016/j.scitotenv.2021.146855. Epub 2021 Apr 1.

Association between ambient particulate matter exposure and metabolic syndrome risk: A systematic review and meta-analysis

Jie Ning  1 , Yaling Zhang  1 , Huaifang Hu  1 , Wentao Hu  1 , Lipeng Li  1 , Yaxian Pang  1 , Shitao Ma  2 , Yujie Niu  3 , Rong Zhang  4
Affiliations
Review

Association between ambient particulate matter exposure and metabolic syndrome risk: A systematic review and meta-analysis

Jie Ning et al. Sci Total Environ. .

Abstract

Although the association between ambient particulate matter and metabolic syndrome (MetS) has been investigated, the effect of particulate matter (PM) on MetS is inconclusive. We conducted a systematic review and meta-analysis to study the association between long-term ambient PM exposure and MetS risk. The data from five databases were extracted to analyze the association between ambient PM exposure and MetS risk. A random-effects model was performed to estimate the overall risk effect. The present systematic review and meta-analysis illustrated that an increase of 5 μg/m3 in annual PM2.5 or PM10 concentration was associated with 14% or 9% increases of MetS risk, respectively (PM2.5, RR = 1.14, 95%CI [1.03, 1.25]; PM10, RR = 1.09, 95%CI [1.00, 1.19]). The population-attributable risk (PAR) was 12.28% for PM2.5 exposure or 8.26% for PM10 exposure, respectively. There was statistical association between PM2.5 exposure and risk of MetS in male proportion ≥50%, Asia, related disease or medication non-adjustment subgroup as well as cohort study subgroups, respectively. The significant association between PM10 exposure and risk of MetS was observed in male proportion ≥50% and calories intake adjustment subgroups, respectively. Sensitivity analyses showed the robustness of our results. No publication bias was detected. In conclusion, there was positive association between long-term PM exposure and MetS risk. 12.28% of MetS risk could be attributable to PM2.5 exposure.

Keywords: Air pollution; Meta-analysis; Metabolic syndrome; Particulate matter; Systematic review.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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