Oxidative stress and its role in cancer
- PMID: 33723127
- DOI: 10.4103/jcrt.JCRT_862_16
Oxidative stress and its role in cancer
Abstract
Reactive oxygen species (ROS) can damage lipids, nucleic acids, and proteins, thereby altering their functions. When a balance between production of ROS and antioxidative defense is disturbed, state of oxidative stress occurs. Oxidative stress leads to many diseases. There are few biomarkers that are used for better understanding how oxidative stress is involved in cancer pathophysiology. This review focuses on 8-hidroxy-2-deoxyguanosine (8-OHdG) and antioxidative enzymes as biomarkers for measurement of oxidative stress in different types of cancer. This review also deals with the product of lipid peroxidation, malondialdehyde (MDA), and across a variety of cancers. To address this aim, analysis of studies of breast, prostate, lung, colon, cervical, ovarian, brain, bladder, renal, thyroid cancer, and chronic lymphocytic leukemia has been conducted. In general, levels of antioxidative enzymes are mostly lower in cancer patients, while 8-OHdG and MDA are higher. Further research is needed, with focus on correlation levels of these biomarkers and advancement of the disease. Moreover, all studies explored the idea of those biomarkers as a useful tool in determining the levels of oxidative stress. Some of the studies proposed their potential in defining the stage of tumor progression.
Keywords: 8-hidroxy-2-deoxyguanosine; antioxidative enzymes; cancer; malondialdehyde; oxidative stress.
Conflict of interest statement
None
Similar articles
-
Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives.Genes (Basel). 2024 Apr 25;15(5):539. doi: 10.3390/genes15050539. Genes (Basel). 2024. PMID: 38790168 Free PMC article. Review.
-
Oxidative Stress and Microglial Response in Retinitis Pigmentosa.Int J Mol Sci. 2020 Sep 28;21(19):7170. doi: 10.3390/ijms21197170. Int J Mol Sci. 2020. PMID: 32998461 Free PMC article. Review.
-
Prognostic impact of 8-hydroxy-deoxyguanosine and its repair enzyme 8-hydroxy-deoxyguanosine DNA glycosylase in hepatocellular carcinoma.Pathol Int. 2020 Aug;70(8):533-541. doi: 10.1111/pin.12952. Epub 2020 May 17. Pathol Int. 2020. PMID: 32419286
-
Prognostic significance of 8-hydroxy-2'-deoxyguanosine in solid tumors: a meta-analysis.BMC Cancer. 2019 Oct 24;19(1):997. doi: 10.1186/s12885-019-6189-9. BMC Cancer. 2019. PMID: 31651287 Free PMC article.
-
Measuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladder.Investig Clin Urol. 2018 Jul;59(4):252-256. doi: 10.4111/icu.2018.59.4.252. Epub 2018 Jun 14. Investig Clin Urol. 2018. PMID: 29984340 Free PMC article.
Cited by
-
IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions.J Pers Med. 2024 May 3;14(5):488. doi: 10.3390/jpm14050488. J Pers Med. 2024. PMID: 38793070 Free PMC article. Review.
-
Metabolomic Profiling of Floccularia luteovirens from Different Geographical Regions Proposes a Novel Perspective on Their Antioxidative Activities.Antioxidants (Basel). 2024 May 20;13(5):620. doi: 10.3390/antiox13050620. Antioxidants (Basel). 2024. PMID: 38790725 Free PMC article.
-
Physical Activity and Oxidative Stress in Aging.Antioxidants (Basel). 2024 May 1;13(5):557. doi: 10.3390/antiox13050557. Antioxidants (Basel). 2024. PMID: 38790662 Free PMC article. Review.
-
Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production.Curr Issues Mol Biol. 2024 May 13;46(5):4646-4687. doi: 10.3390/cimb46050282. Curr Issues Mol Biol. 2024. PMID: 38785550 Free PMC article. Review.
-
VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells.Int J Mol Sci. 2024 Apr 30;25(9):4874. doi: 10.3390/ijms25094874. Int J Mol Sci. 2024. PMID: 38732093 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources