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. 2021 Jan;38(1):164-180.
doi: 10.1111/pde.14408. Epub 2020 Nov 10.

Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

Andrea L Zaenglein  1 , Moise L Levy  2 , Nicole S Stefanko  3 , Latanya T Benjamin  4 , Anna L Bruckner  5 , Keith Choate  6 , Brittany G Craiglow  6 , John J DiGiovanna  7 , Lawrence F Eichenfield  8 , Peter Elias  9 , Philip Fleckman  10 , Leslie P Lawley  11 , Richard A Lewis  12 , Anne W Lucky  13 , Erin F Mathes  9   14 , Leonard M Milstone  6 , Amy S Paller  15 , Sonali S Patel  16 , Dawn H Siegel  17 , Joyce Teng  18 , Sherry A Tanumihardjo  19 , Lauren Thaxton  20 , Mary L Williams  14 ; PeDRA Use of Retinoids in Ichthyosis Work Group
Affiliations

Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents

Andrea L Zaenglein et al. Pediatr Dermatol. 2021 Jan.

Abstract

Topical and systemic retinoids have long been used in the treatment of ichthyoses and other disorders of cornification. Due to the need for long-term use of retinoids for these disorders, often beginning in childhood, numerous clinical concerns must be considered. Systemic retinoids have known side effects involving bone and eye. Additionally, potential psychiatric and cardiovascular effects need to be considered. Contraceptive concerns, as well as the additive cardiovascular and bone effects of systemic retinoid use with hormonal contraception must also be deliberated for patients of childbearing potential. The Pediatric Dermatology Research Alliance (PeDRA) Use of Retinoids in Ichthyosis Work Group was formed to address these issues and to establish best practices regarding the use of retinoids in ichthyoses based on available evidence and expert opinion.

Keywords: adverse drug effects; bone health; contraception; depression; disorder of cornification; drug monitoring; ectropion; hyperlipidemia; iPLEDGE; ichthyosis; quality of life; retinoid; safety monitoring; systemic therapy; topical therapy.

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Conflict of interest statement

Andrea L. Zaenglein, MD was an investigator for Abbvie and Incyte, was on an advisory board for Cassiopea, was an investigator and consultant for Pfizer and Sun Pharmaceuticals, was on an advisory board for Verrica, is an editor‐in‐chief for Pediatric Dermatology, and was an author for UpToDate. Moise L. Levy, MD was on an advisory board and consultant for Cassiopea, Regeneron, and UCB, was an investigator for Fibrocell, Galderma, Janssen, and Pfizer, was on a DSMB for Novan, and was a section editor and author for UpToDate. Latanya T. Benjamin, MD was a consultant for Dove, was on a speakers bureau for Regeneron and Sanofi Genzyme, was on an advisory board and consultant for Mustela, CeraVe, and La Roche‐Posay, was on an advisory board for Bioderma, Cutanea, Biofrontera, Menlo Therapeutics, and Pfizer. Anna L. Bruckner, MD was a investigator for Mayne Pharma. Keith Choate, MD, PhD was on a advisory board and speaker for Abbvie and Janssen, was a consultant and investigator for Mayne Pharma, was a consultant for Timber Pharmaceuticals, and was an author for UpToDate. Brittany G. Craiglow, MD was on a advisory board and consultant for Aclaris, was on an advisory board for Arena Pharmaceuticals, was a consultant for Concert Pharmaceuticals, was on an advisory board, consultant, and speaker for Pfizer, and was a speaker for Regeneron and Sanofi‐Genzyme. Lawrence F. Eichenfield, MD was an investigator and consultant for Abbvie, was on an advisory board for Cassiopea, was an investigator and consultant for Galderma, Incyte, Pfizer, Regeneron, Sanofi‐Genzyme, and Verrica, and was an author for UpToDate. Nicole Stefanko, MD, John DiGiovanna, MD, Peter Elias, MD, Philip Fleckman, MD, Richard Alan Lewis, MD, Anne W. Lucky, MD, Leonard M. Milstone, MD, Sonali S. Patel, MD, Joyce Teng, MD, PhD, Lauren Thaxton MD, MBA, MSBS, and Mary L. Williams, MD: None. Leslie Potter Lawley, MD was an author for UpToDate. Erin F. Mathes, MD was a consultant for Aldeyra Therapeutics and Rodan + Fields, was an author for UpToDate, and was a consultant for Pierre Fabre Amy S. Paller, MD was an investigator in AbbVie, Anaptysbio, Celgene, Eli Lilly, Incyte, and Janssen, was a consultant for Almirall, Amgen, Asana, Boehringer‐Ingelheim, Castle Creek, Dermavant, Dermira, Exicure, Lenus, MEDA Corp, Meiji Seika, Novan, Pfizer, Sanofi‐Genzyme, and Sol Gel, was an investigator and consultantfor Galderma, Leo, Novartis, and Regeneron. Dawn H. Siegel, MD was a consultant ifor Arqule, was an author for UpToDate, and was an investigator for SUN. Sherry A. Tanumihardjo, PhD was on an expert panel for the World Health Organization.

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