Chronic social defeat stress mouse model: Current view on its behavioral deficits and modifications
- PMID: 33090813
- DOI: 10.1037/bne0000418
Chronic social defeat stress mouse model: Current view on its behavioral deficits and modifications
Abstract
Stress is the main cause of mood disorders such as depression and posttraumatic stress disorder. Individuals respond to stress differently, as some develop depressive symptoms, whereas others successfully cope with adversity, but it remains unclear what makes some particularly vulnerable to stress. The chronic social defeat stress (CSDS) mouse model, an ethologically valid rodent model that exhibits long-term physiological and behavioral phenotypes similar to depression and anxiety, can imitate individual differences in stress responses in humans. In this review, we not only summarize various behavioral deficits of the CSDS mouse model that were reported since its establishment but also concentrate on modified CSDS mouse models that have been developed in recent years, aiming at providing useful information for future research and application of this model. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Similar articles
-
Reproducible induction of depressive-like behavior in C57BL/6J mice exposed to chronic social defeat stress with a modified sensory contact protocol.Life Sci. 2021 Oct 1;282:119821. doi: 10.1016/j.lfs.2021.119821. Epub 2021 Jul 13. Life Sci. 2021. PMID: 34271059
-
Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice.Biochem Biophys Res Commun. 2021 May 14;553:107-113. doi: 10.1016/j.bbrc.2021.03.058. Epub 2021 Mar 22. Biochem Biophys Res Commun. 2021. PMID: 33765554
-
Effect of Toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress.Brain Behav. 2020 Mar;10(3):e01525. doi: 10.1002/brb3.1525. Epub 2020 Jan 16. Brain Behav. 2020. PMID: 31945269 Free PMC article.
-
The contagion of social defeat stress: Insights from rodent studies.Neurosci Biobehav Rev. 2020 Apr;111:12-18. doi: 10.1016/j.neubiorev.2020.01.011. Epub 2020 Jan 10. Neurosci Biobehav Rev. 2020. PMID: 31931035 Review.
-
Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.Biol Psychiatry. 2020 Sep 1;88(5):381-391. doi: 10.1016/j.biopsych.2020.02.004. Epub 2020 Feb 18. Biol Psychiatry. 2020. PMID: 32228871 Free PMC article. Review.
Cited by
-
Analysis of androgen receptor expression and activity in the mouse brain.Sci Rep. 2024 May 15;14(1):11115. doi: 10.1038/s41598-024-61733-9. Sci Rep. 2024. PMID: 38750183 Free PMC article.
-
Associations between adverse childhood experiences and history of weight cycling.Obes Sci Pract. 2024 Feb 16;10(1):e736. doi: 10.1002/osp4.736. eCollection 2024 Feb. Obes Sci Pract. 2024. PMID: 38371174 Free PMC article.
-
Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice.BMC Neurosci. 2024 Jan 9;25(1):3. doi: 10.1186/s12868-023-00842-z. BMC Neurosci. 2024. PMID: 38195391 Free PMC article.
-
Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats.Neurobiol Stress. 2023 Oct 19;27:100580. doi: 10.1016/j.ynstr.2023.100580. eCollection 2023 Nov. Neurobiol Stress. 2023. PMID: 37920548 Free PMC article.
-
Systematic evaluation of a predator stress model of depression in mice using a hierarchical 3D-motion learning framework.Transl Psychiatry. 2023 May 25;13(1):178. doi: 10.1038/s41398-023-02481-8. Transl Psychiatry. 2023. PMID: 37231005 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical