Modulation of the M. tuberculosis cell envelope between replicating and non-replicating persistent bacteria
- PMID: 33035766
- PMCID: PMC7704923
- DOI: 10.1016/j.tube.2020.102007
Modulation of the M. tuberculosis cell envelope between replicating and non-replicating persistent bacteria
Abstract
The success of Mycobacterium tuberculosis as a human pathogen depends on the bacterium's ability to persist in a quiescent form in oxygen and nutrient-poor host environments. In vitro studies have demonstrated that these restricting environments induce a shift from bacterial replication to non-replicating persistence (NRP). Entry into NRP involves changes in bacterial metabolism and remodeling of the cell envelope. Findings consistent with the phenotypes observed in vitro have been observed in patient and animal model samples. This review focuses on the cell envelope differences seen between replicating and NRP M. tuberculosis and summarizes the ways in which serine/threonine protein kinases (STPKs) may mediate this process.
Keywords: Dormancy; Lipids; Mycobacterium tuberculosis; Mycolic acids.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Competing interests: The authors have no competing interests.
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