Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Dec;52(11):e13806.
doi: 10.1111/and.13806. Epub 2020 Sep 6.

Comparative efficacy and safety of drug treatment for premature ejaculation: A systemic review and Bayesian network meta-analysis

Hanchao Liu  1 , Mingxiao Zhang  2 , Mingchuan Huang  3 , Hongcai Cai  1 , Yadong Zhang  1 , Guihua Liu  4 , Chunhua Deng  1
Affiliations
Meta-Analysis

Comparative efficacy and safety of drug treatment for premature ejaculation: A systemic review and Bayesian network meta-analysis

Hanchao Liu et al. Andrologia. 2020 Dec.

Abstract

To assess the comparative efficacy and safety of drug treatments for premature ejaculation. A systemic review and Bayesian network meta-analysis were executed on randomised controlled trials of drug interventions for premature ejaculation. Intravaginal ejaculation latency time and related adverse effects were outcome measures. A total of 44 RCTs with 11,008 patients were included in our NMA. In therapy <8 weeks, the ranking of drug efficacy was topical creams >selective serotonin reuptake inhibitor (SSRI)+ phosphodiesterase 5 inhibitor (PDE5i) > PDE5i > sertraline > clomipramine > paroxetine > dapoxetine 60 milligram (mg) > dapoxetine 30 mg > fluoxetine>citalopram > duloxetine>placebo. In therapy ≥ 8 weeks, the ranking of drug efficacy was SSRI + PDE5i > topical creams > paroxetine > tramadol > PDE5i > fluoxetine > dapoxetine 60 mg > dapoxetine 30 mg > clomipramine>citalopram > placebo. For total adverse events, clomipramine, dapoxetine 30 mg, dapoxetine 60 mg, paroxetine, PDE5i, SSRI + PDE5i and tramadol had a higher risk than placebo. In conclusion, in ≥8 weeks of therapy, the drug combination of SSRI + PDE5i was the most effective PE therapy. In <8 weeks of therapy, the efficacy of local anaesthetics was best. All drug treatments were ranked better than placebo. In general, drugs with better effects had more obvious side effects.

Keywords: drug treatment; network meta-analysis; premature ejaculation; systematic review.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Abu El-Hamd, M., & Abdelhamed, A. (2018). Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. Andrologia, 50(1), e12829. https://doi.org/10.1111/and.12829
    1. Alghobary, M., El-Bayoumy, Y., Mostafa, Y., Mahmoud, E.-H.- M,., & Amr, M.(2010). Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation. The Journal of Sexual Medicine, 7(8), 2860-2867. https://doi.org/10.1111/j.1743-6109.2010.01789.x
    1. Althof, S. E., McMahon, C. G., Waldinger, M. D., Serefoglu, E. C., Shindel, A. W., Ganesan Adaikan, P., … Torres, L. O. (2014). An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). The Journal of Sexual Medicine, 11(6), 1392-1422. https://doi.org/10.1111/jsm.12504
    1. Anaissie, J., Yafi, F. A., & Hellstrom, W. J. G. (2016). Surgery is not indicated for the treatment of premature ejaculation. Translational Andrology and Urology, 5(4), 607-612. https://doi.org/10.21037/tau.2016.03.10
    1. Arafa, M., & Shamloul, R. (2006). Efficacy of sertraline hydrochloride in treatment of premature ejaculation: A placebo-controlled study using a validated questionnaire. International Journal of Impotence Research, 18(6), 534-538. https://doi.org/10.1038/sj.ijir.3901469

Substances

LinkOut - more resources