[Determination of antispermal IgE antibodies in women with infertility and chronic inflammatory pelvic diseases]
- PMID: 32762182
- DOI: 10.18821/0869-2084-2020-65-7-435-438
[Determination of antispermal IgE antibodies in women with infertility and chronic inflammatory pelvic diseases]
Abstract
Personalized therapy for female infertility means determining of immune mechanisms, including allergic sensitization towards sperm antigens. In order to determine antisperm serum IgE antibodies in women with infertility suffering from pelvic inflammatory diseases, the modified Anti-Spermatozoa Antibody protocol was used (ASA Serum ELISA, Demeditec Diagnostisc, Germany). The modification of the protocol is designed to detect only serum antisperm IgE antibodies carrying Fab fragments to sperm antigens. Allergen-specific IgEs to a common panel of 176 respiratory and food allergenic molecules were determined using the MeDALL scientific chip developed as a part of the European project. Forty patients suffering from infertility of inflammatory etiology and 16 practically healthy women of reproductive age were examined. Specific IgE antibodies towards sperm antigens were detected in blood serum in 7/40 (17.5%) patients with infertility. The maximum level of sIgE was 4 times higher than the maximal value of fertile women. No correlation with total IgE was detected. Women with sIgE-ASA complained of burning and itching immediately after coition. Systemic and long-term allergic reactions were not noted. Women with positive sIgE-ASA values were 2 times more likely to suffer from chronic recurrent vaginal dysbiosis. The presence of specific anti-sperm IgE antibodies is likely to have pathogenetic significance in female infertility, and they should be taken into consideration for creating personalized therapy approaches.
Keywords: IgE antibodies to sperm; infertility; inflammatory pelvic diseases.
Conflict of interest statement
The authors declare no conflict of interest.
Similar articles
-
Flow cytometry study on the effect of serum and peritoneal fluid of women on sperm-binding activity of immunoglobulin G antisperm antibodies.Fertil Steril. 1997 Apr;67(4):680-6. doi: 10.1016/s0015-0282(97)81366-0. Fertil Steril. 1997. PMID: 9093194
-
Antiidiotypic antibodies to sperm in sera of fertile women that neutralize antisperm antibodies.J Clin Invest. 1993 Nov;92(5):2331-8. doi: 10.1172/JCI116837. J Clin Invest. 1993. PMID: 8227348 Free PMC article.
-
Antisperm antibodies: origin, regulation, and sperm reactivity in human infertility.Fertil Steril. 1994 Jun;61(6):1001-13. doi: 10.1016/s0015-0282(16)56747-8. Fertil Steril. 1994. PMID: 8194608 Review.
-
Immunoglobulin E levels and antisperm antibody titers in infertile couples.Am J Obstet Gynecol. 1981 Aug 15;140(8):923-30. doi: 10.1016/0002-9378(81)90086-7. Am J Obstet Gynecol. 1981. PMID: 7270605
-
The use of antibodies developed by infertile women to identify relevant antigens.Acta Endocrinol Suppl (Copenh). 1975;194:376-404. doi: 10.1530/acta.0.080s376. Acta Endocrinol Suppl (Copenh). 1975. PMID: 1092120 Review.
References
-
- Brazdova A., Senechal H., Peltre G., Poncet P. Immune Aspects of Female Infertility. Int. J. Fertil Steril. 2016; 10: 1-10.
-
- Deroux A., Dumestre-Perard C., Dunand-Faure C., Bouillet L., Hoffmann P. Female infertility and serum auto-antibodies: a systematic review. Clin. Rev. Allergy Immunol. 2017; 53: 78-86.
-
- Popov A. A., Manannikova T. N., Kolesnik N. A., Ramazanov M. R., Fedorov A. A., Barto R. A., Zemskov U. V. Antiadhesion bariers application in infertile patients with pelvic adhesions. Zhurnal akushestva i zhenskikh bolezney. 2012; 4: 97-103. (in Russian)
-
- Sonnex C. Genital allergy. Sex Transm Infect. 2004; 80: 4-7.
-
- Brázdová A., Vermachová M., Zídková J., Sénéchal H., Poncet P., Ulčová-Gallová Z., Peltre G. Immunodominant semen proteins II: contribution of seminal proteins to female immune infertility. Folia Biol (Praha). 2013; 59: 198-203.