Clinical Trial

. 2020 Oct;59(5):102875.

doi: 10.1016/j.transci.2020.102875. Epub 2020 Jul 15.

Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study

Hassan Abolghasemi¹, Peyman Eshghi², Abdol Majid Cheraghali³, Abbas Ali Imani Fooladi¹, Farzaneh Bolouki Moghaddam⁴, Sina Imanizadeh⁴, Matin Moeini Maleki⁴, Mohammad Ranjkesh⁴, Mohammad Rezapour⁴, Ali Bahramifar⁵, Behzad Einollahi⁶, Mohammad Javad Hosseini⁷, Nematollah Joneidi Jafari⁸, Mohamad Nikpouraghdam⁶, Nariman Sadri⁹, Mokhtar Tazik⁹, Shanaz Sali¹⁰, Shamsi Okati¹¹, Elham Askari¹², Payam Tabarsi¹², Jafar Aslani¹³, Ehsan Sharifipour¹⁴, Mohammad Hossein Jarahzadeh¹⁵, Nastaran Khodakarim¹⁶, Mahmood Salesi¹³, Ramezan Jafari¹³, Samira Shahverdi¹⁷

Affiliations

¹ Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
² Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences and Iran Blood Transfusion Organization, Tehran, Iran.
³ School of Pharmacy and Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: majidcheraghali@gmail.com.
⁴ Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁵ Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁶ Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁷ Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁸ Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁹ Darman Ara PJS Company, Tehran, Iran.
¹⁰ Infectious Disease and Tropical Medicine Research Center, Shahid Behesti University of Medical Sciences, Tehran, Iran.
¹¹ High Institute for Research and Education in Transfuion Medicine, Tehran, Iran.
¹² National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹³ Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
¹⁴ Neuroscience Research Center of Qom University of Medical Science, Qom, Iran.
¹⁵ Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
¹⁶ Department of Medical Oncology and Hematology, Iran University of Medical Sciences, Tehran, Iran.
¹⁷ Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.

PMID: 32694043
PMCID: PMC7362821
DOI: 10.1016/j.transci.2020.102875

Clinical Trial

Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study

Hassan Abolghasemi et al. Transfus Apher Sci. 2020 Oct.

. 2020 Oct;59(5):102875.

doi: 10.1016/j.transci.2020.102875. Epub 2020 Jul 15.

Authors

Affiliations

¹ Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
² Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences and Iran Blood Transfusion Organization, Tehran, Iran.
³ School of Pharmacy and Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: majidcheraghali@gmail.com.
⁴ Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁵ Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁶ Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁷ Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁸ Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁹ Darman Ara PJS Company, Tehran, Iran.
¹⁰ Infectious Disease and Tropical Medicine Research Center, Shahid Behesti University of Medical Sciences, Tehran, Iran.
¹¹ High Institute for Research and Education in Transfuion Medicine, Tehran, Iran.
¹² National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹³ Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
¹⁴ Neuroscience Research Center of Qom University of Medical Science, Qom, Iran.
¹⁵ Department of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
¹⁶ Department of Medical Oncology and Hematology, Iran University of Medical Sciences, Tehran, Iran.
¹⁷ Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.

PMID: 32694043
PMCID: PMC7362821
DOI: 10.1016/j.transci.2020.102875

Abstract

Since Dec. 2019 the new coronavirus (SARS-CoV-2) has infected millions and claimed life of several hundred thousand worldwide. However, so far no approved vaccine or drug therapy is available for treatment of virus infection. Convalescent plasma has been considered a potential modality for COVID-19 infection. One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. Comparison of outcomes including all-cause mortality, total hospitalization days and patients' need for intubation between the two patient groups shows that total of 98 (98.2 %) of patients who received convalescent plasma were discharged from hospital which is substantially higher compared to 56 (78.7 %) patients in control group. Length of hospitalization days was significantly lower (9.54 days) in convalescent plasma group compared with that of control group (12.88 days). Only 8 patients (7%) in convalescent plasma group required intubation while that was 20 % in control group. This clinical study provides strong evidence to support the efficacy of convalescent plasma therapy in COVID-19 patients and recommends this treatment for management of these patients. Clinical efficacy, immediate availability and potential cost effectiveness could be considered as main advantages of convalescent plasma therapy.

Keywords: COVID-19; Clinical trial; Convalescent plasma; Hospital stay; Mortality rate.

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Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study

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Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study

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