Vagus nerve stimulation for treatment-resistant depression: is this therapy distinct from other antidepressant treatments?
- PMID: 32677482
- DOI: 10.1080/13651501.2020.1779751
Vagus nerve stimulation for treatment-resistant depression: is this therapy distinct from other antidepressant treatments?
Abstract
Background: The treatment-resistant depression (TRD) is a very disabling disease.
Objective: The aim of this article is to provide an overview of the therapeutic activity of vagus nerve stimulation (VNS) therapy system in TRD. We summarised the progress made during the last decade in this area.
Methods: We conducted a non-systematic review on the efficacy and safety of the VNS therapy for this disease. We analysed the results from acute and long-term studies that utilised this technique. Major electronic databases were searched.
Results: The patients with TRD may show acute and long-term benefit when treated with this technique. There are promising results for VNS therapy for these patients. The level of evidence as an acute treatment option is only 3, but as chronic treatment is 2. This therapy should be offered as an added long-term treatment option for patients with chronic and recurrent difficult to treat depression.
Conclusions: The antidepressant effects of this procedure remain controversial. The clinical trials have produced mixed results, but VNS therapy for TRD has two distinct features that differentiate it from other antidepressant treatments: a sustained therapeutic response obtained in highly resistant depressive disorders, a favourable safety profile and guaranteed compliance.
Keywords: Neurostimulation; clinical trials; neuroprotection; technological advances; treatment-refractory depression; vagus nerve stimulation.
Similar articles
-
Vagus nerve stimulation: An update on a novel treatment for treatment-resistant depression.J Neurol Sci. 2022 Mar 15;434:120171. doi: 10.1016/j.jns.2022.120171. Epub 2022 Jan 29. J Neurol Sci. 2022. PMID: 35158102 Review.
-
Adjunctive Vagus Nerve Stimulation for Treatment-Resistant Depression: a Quantitative Analysis.Psychiatr Q. 2020 Sep;91(3):669-679. doi: 10.1007/s11126-020-09726-5. Psychiatr Q. 2020. PMID: 32144640
-
Advances in brain stimulation for depression.Ann Clin Psychiatry. 2013 Aug;25(3):217-24. Ann Clin Psychiatry. 2013. PMID: 23926577 Review.
-
[Vagus Nerve Stimulation for Affective Disorders].Fortschr Neurol Psychiatr. 2020 Jan;88(1):40-51. doi: 10.1055/a-1003-6678. Epub 2020 Jan 27. Fortschr Neurol Psychiatr. 2020. PMID: 31986551 German.
-
Long-term Sustained Cognitive Benefits of Vagus Nerve Stimulation in Refractory Depression.J ECT. 2018 Dec;34(4):283-290. doi: 10.1097/YCT.0000000000000502. J ECT. 2018. PMID: 29870432
Cited by
-
Cervical muscle stiffness and parasympathetic nervous system improvements for treatment-resistant depression.BMC Musculoskelet Disord. 2022 Oct 11;23(1):907. doi: 10.1186/s12891-022-05860-2. BMC Musculoskelet Disord. 2022. PMID: 36217161 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical