COVID-19 in kidney transplant recipients: A multicenter experience in Istanbul
- PMID: 32657540
- PMCID: PMC7404438
- DOI: 10.1111/tid.13371
COVID-19 in kidney transplant recipients: A multicenter experience in Istanbul
Abstract
Introduction: Management of COVID-19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. However, there is no consensus on this issue yet. This study aimed to our experiences with kidney transplant recipients diagnosed with COVID-19.
Material and methods: Kidney transplant recipients diagnosed with COVID-19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. Patients were classified as having moderate or severe pneumonia for the analysis. The primary endpoint was all-cause mortality. The secondary endpoints were acute kidney injury, the average length of hospital stay, admission to intensive care, and mechanical ventilation.
Results: Forty patients were reviewed retrospectively over a follow-up period of 32 days after being diagnosed with COVID-19. Cough, fever, and dyspnea were the most frequent symptoms in all patients. The frequency of previous induction and rejection therapy was significantly higher in the group with severe pneumonia compared to the moderate pneumonia group. None of the patients using cyclosporine A developed severe pneumonia. Five patients died during follow-up in the intensive care unit. None of the patients developed graft loss during follow-up.
Discussion: COVID-19 has been seen to more commonly cause moderate or severe pneumonia in kidney transplant recipients. Immunosuppression should be carefully reduced in these patients. Induction therapy with lymphocyte-depleting agents should be carefully avoided in kidney transplant recipients during the pandemic period.
Keywords: COVID-19; acute kidney injury; adult; antiviral agents; cytokine release syndrome; cytokine-targeted therapy; kidney transplantation; respiratory distress syndrome.
© 2020 Wiley Periodicals LLC.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
![FIGURE 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/7404438/bin/TID-22-0-g001.gif)
![FIGURE 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/7404438/bin/TID-22-0-g002.gif)
Similar articles
-
COVID-19 pneumonia in kidney transplant recipients: Focus on immunosuppression management.Transpl Infect Dis. 2020 Oct;22(5):e13378. doi: 10.1111/tid.13378. Epub 2020 Jul 6. Transpl Infect Dis. 2020. PMID: 32573882 Free PMC article.
-
Successful recovery from severe COVID-19 pneumonia after kidney transplantation: The interplay between immunosuppression and novel therapy including tocilizumab.Transpl Infect Dis. 2020 Oct;22(5):e13334. doi: 10.1111/tid.13334. Epub 2020 Jun 2. Transpl Infect Dis. 2020. PMID: 32449235 Free PMC article.
-
SARS-CoV-2 infection in kidney transplant recipients: Experience of the italian marche region.Transpl Infect Dis. 2020 Oct;22(5):e13377. doi: 10.1111/tid.13377. Epub 2020 Jul 28. Transpl Infect Dis. 2020. PMID: 32573895 Free PMC article.
-
COVID-19 pneumonia in kidney transplant recipients-Where we are?Transpl Infect Dis. 2020 Oct;22(5):e13306. doi: 10.1111/tid.13306. Epub 2020 May 26. Transpl Infect Dis. 2020. PMID: 32364677 Free PMC article. Review.
-
COVID-19 in an HIV-positive kidney transplant recipient.Transpl Infect Dis. 2020 Oct;22(5):e13338. doi: 10.1111/tid.13338. Epub 2020 Aug 2. Transpl Infect Dis. 2020. PMID: 32453483 Free PMC article. Review.
Cited by
-
SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation.Sci Rep. 2024 Feb 14;14(1):3766. doi: 10.1038/s41598-024-53863-x. Sci Rep. 2024. PMID: 38355742 Free PMC article.
-
Immune characteristics of kidney transplant recipients with acute respiratory distress syndrome induced by COVID-19 at single-cell resolution.Respir Res. 2024 Jan 18;25(1):34. doi: 10.1186/s12931-024-02682-9. Respir Res. 2024. PMID: 38238762 Free PMC article.
-
Outcome of COVID-19 in Egyptian living-donor kidney transplant recipients and relation to maintenance immunosuppressive drugs: a pilot study.Sci Rep. 2023 Nov 3;13(1):19002. doi: 10.1038/s41598-023-45750-8. Sci Rep. 2023. PMID: 37923735 Free PMC article.
-
Preparing for the next viral threat with broad-spectrum antivirals.J Clin Invest. 2023 Jun 1;133(11):e170236. doi: 10.1172/JCI170236. J Clin Invest. 2023. PMID: 37259914 Free PMC article. Review.
-
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models.Front Cell Infect Microbiol. 2022 Sep 21;12:958634. doi: 10.3389/fcimb.2022.958634. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36211973 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical