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. 2020 Dec;61(12):2955-2961.
doi: 10.1080/10428194.2020.1790555. Epub 2020 Jul 9.

Outcomes for allogeneic stem cell transplantation in refractory mycosis fungoides and primary cutaneous gamma Delta T cell lymphomas

Iris Isufi  1 , Stuart Seropian  1 , Lohith Gowda  1 , Lynn D Wilson  2 , Kenneth Roberts  2 , Michael Girardi  3 , Sarah Perreault  4 , Francine Foss  1
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Outcomes for allogeneic stem cell transplantation in refractory mycosis fungoides and primary cutaneous gamma Delta T cell lymphomas

Iris Isufi et al. Leuk Lymphoma. 2020 Dec.

Abstract

We report results on 23 patients with cutaneous T cell lymphoma (7 primary cutaneous γδ T cell lymphoma [PCGDT], 16 mycosis fungoides/Sézary syndrome [MF/SS]) who underwent allogeneic stem cell transplantation. All pts had skin involvement, 14 had total skin electron beam before conditioning. Donors were 10/10 HLA matched related (13), 5/10 haploidentical (4), and matched unrelated (5) or mismatched unrelated (1). Thirteen were in a clinical complete remission at the time of transplant. The 100-day transplant related mortality for the MF/SS and PCGDT patients was 12% and 29%, respectively. At a median follow up of 5.5 years, the overall survival and disease-free survival for MF/SS patients was 75% and 64%, respectively, and 6 of 10 MF/SS pts in long term complete response had a partial response at the time of transplant. Of seven PCGDT patients, four of seven are alive at a median follow up of 5 years and three are disease-free.

Keywords: Mycosis fungoides; Sézary syndrome; allogeneic stem cell transplant; primary cutaneous gamma delta t cell lymphoma; reduced intensity transplantation.

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