Can vitamin C and interleukin 6 levels predict preterm premature rupture of membranes: evaluating possibilities in North Indian population
- PMID: 32550737
- PMCID: PMC7393753
- DOI: 10.5468/ogs.19188
Can vitamin C and interleukin 6 levels predict preterm premature rupture of membranes: evaluating possibilities in North Indian population
Abstract
Objective: We aimed to evaluate the relation between plasma ascorbic acid levels and the occurrence of preterm premature rupture of membranes (PPROM) and whether patients with ascorbic acid deficiency have predisposition to microbial invasion, as revealed by serum interleukin-6 (IL-6) levels and confirmed by placental culture sensitivity evaluation.
Methods: This controlled study involved 50 women with PPROM at gestational age between 28 and 36.6 weeks. Fifty patients with uncomplicated pregnancy and intact membranes were observed as control group. Serum ascorbic acid and IL-6 levels were evaluated for PPROM group subjects and controls, matched by their gestational age and body mass index. Repeat samples for IL-6 were taken after 48 hours of admission in PROM group subjects and at the onset of labor in controls. Placental membranes were sent for culture sensitivity evaluation after delivery.
Results: The mean plasma level of ascorbic acid was 0.60±0.35 mg/dL and 1.18±0.43 mg/dL in the PPROM and control groups, respectively, showing significant difference. Plasma IL-6 level rose from 18.18±5.94 pg/mL to 34.32±7.31 pg/mL after 48 hours of admission in the PPROM group (P=0.000). Plasma IL-6 level in controls rose from 5.59±4.36 pg/mL at admission to 7.36±3.67 pg/mL at the onset of labor. Membrane culture test results were positive in a total of 40 samples, of which 37 samples were from the PPROM group subjects.
Conclusion: Vitamin C deficiency, when complemented with elevated serum IL-6 level, can predict susceptibility to PPROM in the third trimester; the risk increases in women with prior history of similar pathology.
Keywords: Ascorbic acid; Complications; Interleukin-6; Pregnancy; Preterm premature rupture of fetal membranes.
Conflict of interest statement
No potential conflict of interest relevant to this article was reported.
Figures
Similar articles
-
Vitamin C and IL-6 in women with preterm premature rupture of membranes compared to normal pregnant women - a case-control study.J Pak Med Assoc. 2021 Dec;71(Suppl 8)(12):S45-S48. J Pak Med Assoc. 2021. PMID: 35130217
-
Third trimester preterm and term premature rupture of membranes: Is there any difference in maternal characteristics and pregnancy outcomes?J Chin Med Assoc. 2017 Oct;80(10):657-661. doi: 10.1016/j.jcma.2016.12.006. Epub 2017 Apr 18. J Chin Med Assoc. 2017. PMID: 28431858
-
Value of amniotic fluid IL-8 and Annexin A2 in prediction of preterm delivery in preterm labor and preterm premature rupture of membranes.J Reprod Med. 2014 Mar-Apr;59(3-4):154-60. J Reprod Med. 2014. PMID: 24724224
-
The role of vitamin C in prevention of preterm premature rupture of membranes.Iran Red Crescent Med J. 2013 Feb;15(2):113-6. doi: 10.5812/ircmj.5138. Epub 2013 Feb 5. Iran Red Crescent Med J. 2013. PMID: 23682322 Free PMC article.
-
Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF).Eur J Obstet Gynecol Reprod Biol. 2019 May;236:1-6. doi: 10.1016/j.ejogrb.2019.02.021. Epub 2019 Mar 2. Eur J Obstet Gynecol Reprod Biol. 2019. PMID: 30870741 Review.
Cited by
-
Association of recurrent implantation failure and recurrent pregnancy loss with peripheral blood natural killer cells and interferon-gamma level.Obstet Gynecol Sci. 2024 Jan;67(1):112-119. doi: 10.5468/ogs.23120. Epub 2023 Nov 21. Obstet Gynecol Sci. 2024. PMID: 37986570 Free PMC article.
-
Disrupted Balance of the Oxidant-Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes.Curr Issues Mol Biol. 2023 Oct 4;45(10):8091-8111. doi: 10.3390/cimb45100511. Curr Issues Mol Biol. 2023. PMID: 37886954 Free PMC article. Review.
-
Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy.Antioxidants (Basel). 2022 Mar 28;11(4):648. doi: 10.3390/antiox11040648. Antioxidants (Basel). 2022. PMID: 35453333 Free PMC article. Review.
-
Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003-2006.Nutrients. 2021 Oct 30;13(11):3910. doi: 10.3390/nu13113910. Nutrients. 2021. PMID: 34836166 Free PMC article.
References
-
- Hartling L, Chari R, Friesen C, Vandermeer B, Lacaze-Masmonteil T. A systematic review of intentional delivery in women with preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2006;19:177–87. - PubMed
-
- ACOG Committee on Practice Bulletins-Obstetrics ACOG practice bulletin No. 80: premature rupture of membranes. Clinical management guidelines for obstetrician-gynecologists. Obstet Gynecol. 2007;109:1007–19. - PubMed
-
- Gulati S, Bhatnagar S, Raghunandan C, Bhattacharjee J. Interleukin-6 as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes. Am J Reprod Immunol. 2012;67:235–40. - PubMed
LinkOut - more resources
Full Text Sources