Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties
- PMID: 32484623
Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties
Abstract
Atopic dermatitis is characterized by dry, itchy, inflamed skin with a dysbiotic microbiome. In this clinical study (NCT03673059), we compared the effects of an eczema cream containing 1% colloidal oat and a standard moisturizer on the skin microbiome and skin barrier function of patients with mild to moderate eczema. Patients were randomly assigned to treatment with 1% colloidal oat eczema cream or a standard, non-fragranced daily moisturizer. Treatment lasted 14 days, followed by a 7-day regression period. Of 61 patients who completed the study, 30 received the 1% colloidal oat eczema cream and 31 received the standard moisturizer. At 14 days, the 1% colloidal oat eczema cream reduced mean Eczema Area Severity Index and Atopic Dermatitis Severity Index scores by 51% and 54%, respectively. Unlike treatment with the standard moisturizer, treatment with the 1% colloidal oat eczema cream was associated with trends towards lower prevalence of Staphylococcus species and higher microbiome diversity at lesion sites. The 1% colloidal oat eczema cream significantly improved skin pH, skin barrier function, and skin hydration from baseline to day 14, whereas the standard moisturizer improved hydration. Overall, the results demonstrate that topical products can have differing effects on the skin barrier properties and the microbiome. Importantly, we show that the use of a 1% colloidal oat eczema cream improves microbiome composition and significantly repairs skin barrier defects. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.4924.
Similar articles
-
A 1% colloidal oatmeal OTC cream is clinically effective for the management of mild to moderate atopic dermatitis in Black or African American children.J Dermatolog Treat. 2023 Dec;34(1):2241587. doi: 10.1080/09546634.2023.2241587. J Dermatolog Treat. 2023. PMID: 37592879 Clinical Trial.
-
Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control.J Drugs Dermatol. 2018 Jul 1;17(7):758-764. J Drugs Dermatol. 2018. PMID: 30005098 Clinical Trial.
-
Effects of a protein-free oat plantlet extract on microinflammation and skin barrier function in atopic dermatitis patients.J Eur Acad Dermatol Venereol. 2018 Apr;32 Suppl 1:1-15. doi: 10.1111/jdv.14846. J Eur Acad Dermatol Venereol. 2018. PMID: 29533490 Review.
-
A 1% Colloidal Oatmeal Cream Alone is Effective in Reducing Symptoms of Mild to Moderate Atopic Dermatitis: Results from Two Clinical Studies.J Drugs Dermatol. 2017 Jul 1;16(7):671-676. J Drugs Dermatol. 2017. PMID: 28697218 Clinical Trial.
-
Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema.Hong Kong Med J. 2015 Oct;21(5):417-25. doi: 10.12809/hkmj144472. Epub 2015 Aug 28. Hong Kong Med J. 2015. PMID: 26314567 Review.
Cited by
-
Topical Treatments in Atopic Dermatitis: An Expansive Review.J Clin Med. 2024 Apr 10;13(8):2185. doi: 10.3390/jcm13082185. J Clin Med. 2024. PMID: 38673458 Free PMC article. Review.
-
Skin Deep: The Potential of Microbiome Cosmetics.J Microbiol. 2024 Mar;62(3):181-199. doi: 10.1007/s12275-024-00128-x. Epub 2024 Apr 16. J Microbiol. 2024. PMID: 38625646 Review.
-
The Skin Microbiome and its Significance for Dermatologists.Am J Clin Dermatol. 2024 Mar;25(2):169-177. doi: 10.1007/s40257-023-00842-z. Epub 2024 Jan 22. Am J Clin Dermatol. 2024. PMID: 38252188
-
Bathing in Atopic Dermatitis in Pediatric Age: Why, How and When.Pediatr Rep. 2024 Jan 8;16(1):57-68. doi: 10.3390/pediatric16010006. Pediatr Rep. 2024. PMID: 38251315 Free PMC article. Review.
-
Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies.Pathogens. 2022 Jun 2;11(6):642. doi: 10.3390/pathogens11060642. Pathogens. 2022. PMID: 35745496 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical