The human tumor microbiome is composed of tumor type-specific intracellular bacteria
- PMID: 32467386
- PMCID: PMC7757858
- DOI: 10.1126/science.aay9189
The human tumor microbiome is composed of tumor type-specific intracellular bacteria
Abstract
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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Comment in
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Probing the tumor micro(b)environment.Science. 2020 May 29;368(6494):938-939. doi: 10.1126/science.abc1464. Science. 2020. PMID: 32467376 No abstract available.
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Tumors Appear Rife with Bacterial Lodgers.Cancer Discov. 2020 Aug;10(8):1085-1086. doi: 10.1158/2159-8290.CD-NB2020-062. Epub 2020 Jun 18. Cancer Discov. 2020. PMID: 32554395
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Bacterial residents.Nat Rev Cancer. 2020 Aug;20(8):413. doi: 10.1038/s41568-020-0284-8. Nat Rev Cancer. 2020. PMID: 32572206 No abstract available.
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Cancer-Type-Specific Bacteria: Freeloaders or Partners?Cancer Cell. 2020 Aug 10;38(2):158-160. doi: 10.1016/j.ccell.2020.06.017. Epub 2020 Jul 9. Cancer Cell. 2020. PMID: 32649886
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Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment.Signal Transduct Target Ther. 2020 Jul 29;5(1):136. doi: 10.1038/s41392-020-00244-1. Signal Transduct Target Ther. 2020. PMID: 32728023 Free PMC article. No abstract available.
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