Nutrition and the ageing brain: Moving towards clinical applications

Emma Flanagan¹, Daniel Lamport², Lorraine Brennan³, Philip Burnet⁴, Vittorio Calabrese⁵, Stephen C Cunnane⁶, Martijn C de Wilde⁷, Louise Dye⁸, Jonathan A Farrimond⁹, Nancy Emerson Lombardo¹⁰, Tobias Hartmann¹¹, Thomas Hartung¹², Marko Kalliomäki¹³, Gunther G Kuhnle¹⁴, Giorgio La Fata¹⁵, Aleix Sala-Vila¹⁶, Cécilia Samieri¹⁷, A David Smith¹⁸, Jeremy P E Spencer¹⁴, Sandrine Thuret¹⁹, Kieran Tuohy²⁰, Silvia Turroni²¹, Wim Vanden Berghe²², Martin Verkuijl²³, Karin Verzijden²⁴, Mary Yannakoulia²⁵, Lucie Geurts²⁶, David Vauzour²⁷

Affiliations

¹ Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
² School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading, UK.
³ UCD Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
⁴ Department of Psychiatry, University of Oxford, Oxford, UK.
⁵ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
⁶ Research Center on Aging, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie (CIUSSS) de L'Estrie-Centre hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada; Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁷ Formerly at Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands.
⁸ Currently at Emerging Sciences Research, Reckitt Benckiser, Nijmegen, the Netherlands; Human Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK.
⁹ Lucozade Ribena Suntory Ltd., Uxbridge, UK.
¹⁰ Dept. of Neurology, Boston University School of Medicine and Boston University Alzheimer's Disease Center, USA.
¹¹ German Institute for Dementia Prevention (DIDP), Medical Faculty, and Department of Experimental Neurology, Saarland University, Homburg, Germany.
¹² Centre for Alternative to Animal Testing (CAAT), Johns Hopkins University, Baltimore, USA; University of Konstanz, CAAT-Europe, Konstanz, Germany.
¹³ Department of Pediatrics, University of Turku, Finland.
¹⁴ Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
¹⁵ DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
¹⁶ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
¹⁷ INSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
¹⁸ Oxford Project to Investigate Memory and Aging, University of Oxford, UK.
¹⁹ Institute of Psychiatry, Psychology and Neuroscience, King's College London, The Maurice Wohl Clinical Neuroscience Institute, London, UK.
²⁰ Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.
²¹ Unit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
²² PPES, Department Biomedical Sciences, University Antwerp, Campus Drie Eiken, Antwerp, Belgium.
²³ Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands.
²⁴ Attorney-at-law at Axon Lawyers, the Netherlands.
²⁵ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁶ International Life Sciences Institute Europe (ILSI Europe) a.i.s.b.l., Brussels, Belgium.
²⁷ Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address: D.Vauzour@uea.ac.uk.

PMID: 32461136
DOI: 10.1016/j.arr.2020.101079

Free article

Review

Nutrition and the ageing brain: Moving towards clinical applications

Emma Flanagan et al. Ageing Res Rev. 2020 Sep.

Free article

. 2020 Sep:62:101079.

doi: 10.1016/j.arr.2020.101079. Epub 2020 May 24.

Authors

Affiliations

¹ Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK.
² School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading, UK.
³ UCD Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
⁴ Department of Psychiatry, University of Oxford, Oxford, UK.
⁵ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
⁶ Research Center on Aging, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie (CIUSSS) de L'Estrie-Centre hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada; Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁷ Formerly at Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands.
⁸ Currently at Emerging Sciences Research, Reckitt Benckiser, Nijmegen, the Netherlands; Human Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK.
⁹ Lucozade Ribena Suntory Ltd., Uxbridge, UK.
¹⁰ Dept. of Neurology, Boston University School of Medicine and Boston University Alzheimer's Disease Center, USA.
¹¹ German Institute for Dementia Prevention (DIDP), Medical Faculty, and Department of Experimental Neurology, Saarland University, Homburg, Germany.
¹² Centre for Alternative to Animal Testing (CAAT), Johns Hopkins University, Baltimore, USA; University of Konstanz, CAAT-Europe, Konstanz, Germany.
¹³ Department of Pediatrics, University of Turku, Finland.
¹⁴ Department of Food and Nutritional Sciences, University of Reading, Reading, UK.
¹⁵ DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
¹⁶ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
¹⁷ INSERM, UMR 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
¹⁸ Oxford Project to Investigate Memory and Aging, University of Oxford, UK.
¹⁹ Institute of Psychiatry, Psychology and Neuroscience, King's College London, The Maurice Wohl Clinical Neuroscience Institute, London, UK.
²⁰ Department of Food Quality and Nutrition, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.
²¹ Unit of Microbial Ecology of Health, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
²² PPES, Department Biomedical Sciences, University Antwerp, Campus Drie Eiken, Antwerp, Belgium.
²³ Danone Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, the Netherlands.
²⁴ Attorney-at-law at Axon Lawyers, the Netherlands.
²⁵ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
²⁶ International Life Sciences Institute Europe (ILSI Europe) a.i.s.b.l., Brussels, Belgium.
²⁷ Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address: D.Vauzour@uea.ac.uk.

PMID: 32461136
DOI: 10.1016/j.arr.2020.101079

Abstract

The global increases in life expectancy and population have resulted in a growing ageing population and with it a growing number of people living with age-related neurodegenerative conditions and dementia, shifting focus towards methods of prevention, with lifestyle approaches such as nutrition representing a promising avenue for further development. This overview summarises the main themes discussed during the 3^rd Symposium on "Nutrition for the Ageing Brain: Moving Towards Clinical Applications" held in Madrid in August 2018, enlarged with the current state of knowledge on how nutrition influences healthy ageing and gives recommendations regarding how the critical field of nutrition and neurodegeneration research should move forward into the future. Specific nutrients are discussed as well as the impact of multi-nutrient and whole diet approaches, showing particular promise to combatting the growing burden of age-related cognitive decline. The emergence of new avenues for exploring the role of diet in healthy ageing, such as the impact of the gut microbiome and development of new techniques (imaging measures of brain metabolism, metabolomics, biomarkers) are enabling researchers to approach finding answers to these questions. But the translation of these findings into clinical and public health contexts remains an obstacle due to significant shortcomings in nutrition research or pressure on the scientific community to communicate recommendations to the general public in a convincing and accessible way. Some promising programs exist but further investigation to improve our understanding of the mechanisms by which nutrition can improve brain health across the human lifespan is still required.

Keywords: Brain; Cognitive ageing; Healthy ageing; Microbiota; Neuroprotection; Preventative diet.

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Nutrition and the ageing brain: Moving towards clinical applications

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Nutrition and the ageing brain: Moving towards clinical applications

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