Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 27;2(2):e190058.
doi: 10.1148/rycan.2020190058.

Low-Dose CT Screening for Lung Cancer: Evidence from 2 Decades of Study

David S Gierada  1 , William C Black  1 , Caroline Chiles  1 , Paul F Pinsky  1 , David F Yankelevitz  1
Affiliations
Review

Low-Dose CT Screening for Lung Cancer: Evidence from 2 Decades of Study

David S Gierada et al. Radiol Imaging Cancer. .

Abstract

Lung cancer remains the overwhelmingly greatest cause of cancer death in the United States, accounting for more annual deaths than breast, prostate, and colon cancer combined. Accumulated evidence since the mid to late 1990s, however, indicates that low-dose CT screening of high-risk patients enables detection of lung cancer at an early stage and can reduce the risk of dying from lung cancer. CT screening is now a recommended clinical service in the United States, subject to guidelines and reimbursement requirements intended to standardize practice and optimize the balance of benefits and risks. In this review, the evidence on the effectiveness of CT screening will be summarized and the current guidelines and standards will be described in the context of knowledge gained from lung cancer screening studies. In addition, an overview of the potential advances that may improve CT screening will be presented, and the need to better understand the performance in clinical practice outside of the research trial setting will be discussed. © RSNA, 2020.

PubMed Disclaimer

Conflict of interest statement

Disclosures of Conflicts of Interest: D.S.G. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: Received travel accommodation expenses to attend meetings on quantitative imaging lung cancer screening from RSNA and the International Association for the Study of Lung Cancer; editorial board member for Radiology: Imaging Cancer. Other relationships: disclosed no relevant relationships. W.C.B. disclosed no relevant relationships. C.C. disclosed no relevant relationships. P.F.P. disclosed no relevant relationships. D.F.Y. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: Serves on advisory board for GRAIL, is named as an inventor on numerous patents on applications related to the evaluation of diseases of the chest; some patents are owned by Cornell Research Foundation and are non-exclusively licensed to General Electric, and owns stock in Accumetra. Other relationships: disclosed no relevant relationships.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69(1):7–34. - PubMed
    1. Weiss W.Cigarette smoking and lung cancer trends. A light at the end of the tunnel? Chest 1997;111(5):1414–1416. - PubMed
    1. Jeon J, Holford TR, Levy DT, et al. . Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach. Ann Intern Med 2018;169(10):684–693. - PMC - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394–424. - PubMed
    1. American Cancer Society . Global Cancer Facts & Figures. 4th ed. Atlanta, Ga: American Cancer Society, 2018.