Review

. 2021 May;178(10):2060-2076.

doi: 10.1111/bph.15068. Epub 2020 May 19.

The role of mitochondrial dynamics in cardiovascular diseases

Maurizio Forte¹, Leonardo Schirone^{2

3}, Pietro Ameri^{4

5}, Cristina Basso⁶, Daniele Catalucci^{7

8}, Jessica Modica^{7

8}, Cristina Chimenti⁹, Lia Crotti^{10

11

12}, Giacomo Frati^{1

2}, Speranza Rubattu^{1

13}, Gabriele Giacomo Schiattarella^{14

15}, Daniele Torella¹⁶, Cinzia Perrino¹⁵, Ciro Indolfi¹⁶, Sebastiano Sciarretta^{1

2}; Italian Society of Cardiology Working group on Cellular and Molecular Biology of the Heart

Affiliations

¹ Department of AngioCardioNeurology, IRCCS Neuromed, Pozzili, Italy.
² Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
³ Department of Internal, Anesthetic and Cardiovascular Clinical Sciences, "La Sapienza" University of Rome, Rome, Italy.
⁴ Cardiovascular Disease Unit, IRCCS Ospedale Policlinico, Genova, Italy.
⁵ Department of Internal Medicine, University of Genova, Genova, Italy.
⁶ Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padova, Italy.
⁷ Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.
⁸ National Research Council, Institute of Genetic and Biomedical Research - UOS, Milan, Italy.
⁹ Department of Cardiovascular, Respiratory, Nephrologic, and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.
¹⁰ Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.
¹¹ Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy.
¹² Department of Medicine and Surgery, Università Milano-Bicocca, Milan, Italy.
¹³ Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
¹⁴ Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹⁵ Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
¹⁶ Molecular and Cellular Cardiology Laboratory, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.

PMID: 32294237
DOI: 10.1111/bph.15068

Free article

Review

The role of mitochondrial dynamics in cardiovascular diseases

Maurizio Forte et al. Br J Pharmacol. 2021 May.

Free article

. 2021 May;178(10):2060-2076.

doi: 10.1111/bph.15068. Epub 2020 May 19.

Authors

Affiliations

¹ Department of AngioCardioNeurology, IRCCS Neuromed, Pozzili, Italy.
² Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
³ Department of Internal, Anesthetic and Cardiovascular Clinical Sciences, "La Sapienza" University of Rome, Rome, Italy.
⁴ Cardiovascular Disease Unit, IRCCS Ospedale Policlinico, Genova, Italy.
⁵ Department of Internal Medicine, University of Genova, Genova, Italy.
⁶ Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Padova, Italy.
⁷ Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.
⁸ National Research Council, Institute of Genetic and Biomedical Research - UOS, Milan, Italy.
⁹ Department of Cardiovascular, Respiratory, Nephrologic, and Geriatric Sciences, Sapienza University of Rome, Rome, Italy.
¹⁰ Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.
¹¹ Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy.
¹² Department of Medicine and Surgery, Università Milano-Bicocca, Milan, Italy.
¹³ Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
¹⁴ Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹⁵ Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy.
¹⁶ Molecular and Cellular Cardiology Laboratory, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.

PMID: 32294237
DOI: 10.1111/bph.15068

Abstract

The process of mitochondrial dynamics is emerging as a core player in cardiovascular homeostasis. This process refers to the co-ordinated cycles of biogenesis, fusion, fission and degradation to which mitochondria constantly undergo to maintain their integrity, distribution and size. These mechanisms represent an early response to mitochondrial stress, confining organelle portions that are irreversibly damaged and preserving mitochondrial function. Accumulating evidence demonstrates that impairment in mitochondrial dynamics leads to myocardial damage and cardiac disease progression in a variety of disease models, including pressure overload, ischaemia/reperfusion and metabolic disturbance. These findings suggest that modulation of mitochondrial dynamics may be considered as a valid therapeutic strategy in cardiovascular diseases. In this review, we discuss the current evidence about the role of mitochondrial dynamics in cardiac pathophysiology, with a particular focus on the mechanisms underlying the development of cardiac hypertrophy and heart failure, metabolic and genetic cardiomyopathies, ischaemia/reperfusion injury, atherosclerosis and ischaemic stroke. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.

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The role of mitochondrial dynamics in cardiovascular diseases

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The role of mitochondrial dynamics in cardiovascular diseases

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