Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations
- PMID: 32265562
- DOI: 10.1038/s41587-020-0471-x
Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations
Erratum in
-
Author Correction: Efficient production of male Wolbachia-infected Aedes aegypti mosquitoes enables large-scale suppression of wild populations.Nat Biotechnol. 2020 Aug;38(8):1000. doi: 10.1038/s41587-020-0649-2. Nat Biotechnol. 2020. PMID: 32710084
Abstract
The range of the mosquito Aedes aegypti continues to expand, putting more than two billion people at risk of arboviral infection. The sterile insect technique (SIT) has been used to successfully combat agricultural pests at large scale, but not mosquitoes, mainly because of challenges with consistent production and distribution of high-quality male mosquitoes. We describe automated processes to rear and release millions of competitive, sterile male Wolbachia-infected mosquitoes, and use of these males in a large-scale suppression trial in Fresno County, California. In 2018, we released 14.4 million males across three replicate neighborhoods encompassing 293 hectares. At peak mosquito season, the number of female mosquitoes was 95.5% lower (95% CI, 93.6-96.9) in release areas compared to non-release areas, with the most geographically isolated neighborhood reaching a 99% reduction. This work demonstrates the high efficacy of mosquito SIT in an area ninefold larger than in previous similar trials, supporting the potential of this approach in public health and nuisance-mosquito eradication programs.
Comment in
-
Reply to: Assessing the efficiency of Verily's automated process for production and release of male Wolbachia-infected mosquitoes.Nat Biotechnol. 2022 Oct;40(10):1443-1446. doi: 10.1038/s41587-022-01325-y. Epub 2022 May 26. Nat Biotechnol. 2022. PMID: 35618925 No abstract available.
-
Assessing the efficiency of Verily's automated process for production and release of male Wolbachia-infected mosquitoes.Nat Biotechnol. 2022 Oct;40(10):1441-1442. doi: 10.1038/s41587-022-01324-z. Epub 2022 May 26. Nat Biotechnol. 2022. PMID: 35618926 No abstract available.
Similar articles
-
Combined sterile insect technique and incompatible insect technique: sex separation and quality of sterile Aedes aegypti male mosquitoes released in a pilot population suppression trial in Thailand.Parasit Vectors. 2018 Dec 24;11(Suppl 2):657. doi: 10.1186/s13071-018-3214-9. Parasit Vectors. 2018. PMID: 30583749 Free PMC article.
-
Incompatible and sterile insect techniques combined eliminate mosquitoes.Nature. 2019 Aug;572(7767):56-61. doi: 10.1038/s41586-019-1407-9. Epub 2019 Jul 17. Nature. 2019. PMID: 31316207
-
Combined sterile insect technique and incompatible insect technique: The first proof-of-concept to suppress Aedes aegypti vector populations in semi-rural settings in Thailand.PLoS Negl Trop Dis. 2019 Oct 28;13(10):e0007771. doi: 10.1371/journal.pntd.0007771. eCollection 2019 Oct. PLoS Negl Trop Dis. 2019. PMID: 31658265 Free PMC article.
-
Mission Accomplished? We Need a Guide to the 'Post Release' World of Wolbachia for Aedes-borne Disease Control.Trends Parasitol. 2018 Mar;34(3):217-226. doi: 10.1016/j.pt.2017.11.011. Epub 2018 Jan 23. Trends Parasitol. 2018. PMID: 29396201 Review.
-
The Use of Wolbachia by the World Mosquito Program to Interrupt Transmission of Aedes aegypti Transmitted Viruses.Adv Exp Med Biol. 2018;1062:355-360. doi: 10.1007/978-981-10-8727-1_24. Adv Exp Med Biol. 2018. PMID: 29845544 Review.
Cited by
-
Wolbachia impacts microbiome diversity and fitness-associated traits for Drosophila melanogaster in a seasonally fluctuating environment.Ecol Evol. 2024 Jul 22;14(7):e70004. doi: 10.1002/ece3.70004. eCollection 2024 Jul. Ecol Evol. 2024. PMID: 39041013 Free PMC article.
-
Challenges of Robust RNAi-Mediated Gene Silencing in Aedes Mosquitoes.Int J Mol Sci. 2024 May 10;25(10):5218. doi: 10.3390/ijms25105218. Int J Mol Sci. 2024. PMID: 38791257 Free PMC article.
-
A survey of Wolbachia infection in brachyceran flies from Iran.PLoS One. 2024 May 22;19(5):e0301274. doi: 10.1371/journal.pone.0301274. eCollection 2024. PLoS One. 2024. PMID: 38776328 Free PMC article.
-
Genetic variability of Aedes aegypti (Diptera: Culicidae) in El Salvador and Honduras: presence of a widespread haplotype and implications for mosquito control.Parasit Vectors. 2024 May 16;17(1):229. doi: 10.1186/s13071-024-06312-7. Parasit Vectors. 2024. PMID: 38755689 Free PMC article.
-
Updates on traditional methods for combating malaria and emerging Wolbachia-based interventions.Front Cell Infect Microbiol. 2024 Apr 23;14:1330475. doi: 10.3389/fcimb.2024.1330475. eCollection 2024. Front Cell Infect Microbiol. 2024. PMID: 38716193 Free PMC article. Review.
References
-
- Powell, J. R., Gloria-Soria, A. & Kotsakiozi, P. Recent history of Aedes aegypti: vector genomics and epidemiology records. Bioscience 68, 854–860 (2018). - DOI
-
- Engelthaler, D. M., Fink, T. M., Levy, C. E. & Leslie, M. J. The re-emergence of Aedes aegypti in Arizona. Emerging Infect. Dis 3, 241–242 (1997). - DOI
-
- Metzger, M. E., Hardstone Yoshimizu, M., Padgett, K. A., Hu, R. & Kramer, V. L. Detection and establishment of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) mosquitoes in California, 2011-2015. J. Med. Entomol. 54, 533–543 (2017). - DOI
-
- Kraemer, M. U. G. et al. The global compendium of Aedes aegypti and Ae. albopictus occurrence. Sci. Data 2, 150035 (2015). - DOI
-
- Soper, F. L. The elimination of urban yellow fever in the americas through the eradication of Aedes aegypti. Am. J. Public Health Nations Health 53, 7–16 (1963). - DOI
MeSH terms
LinkOut - more resources
Full Text Sources