Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Affiliations

¹ Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
² Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
³ Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁴ Department of Molecular Medicine and Genetics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁵ Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁶ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁷ Department of Microbiology, School of Health, Tehran University of Medical Sciences, Tehran, Iran.
⁸ School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁹ Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: yousefimashouf@umsha.ac.ir.

PMID: 32045645
DOI: 10.1016/j.micpath.2020.104052

Review

Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Rasoul Mirzaei et al. Microb Pathog. 2020.

. 2020 Feb 8:142:104052.

doi: 10.1016/j.micpath.2020.104052. Online ahead of print.

Affiliations

¹ Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
² Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
³ Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁴ Department of Molecular Medicine and Genetics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁵ Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁶ Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁷ Department of Microbiology, School of Health, Tehran University of Medical Sciences, Tehran, Iran.
⁸ School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁹ Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: yousefimashouf@umsha.ac.ir.

PMID: 32045645
DOI: 10.1016/j.micpath.2020.104052

Abstract

Human colorectal cancer is the third most common cancer around the world. Colorectal cancer has various risk factors, but current works have bolded a significant activity for the microbiota of the human colon in the development of this disease. Bacterial biofilm has been mediated to non-malignant pathologies like inflammatory bowel disease but has not been fully documented in the setting of colorectal cancer. The investigation has currently found that bacterial biofilm is mediated to colon cancer in the human and linked to the location of human cancer, with almost all right-sided adenomas of colon cancers possessing bacterial biofilm, whilst left-sided cancer is rarely biofilm positive. The profound comprehension of the changes in colorectal cancer can provide interesting novel concepts for anticancer treatments. In this review, we will summarize and examine the new knowledge about the links between colorectal cancer and bacterial biofilm.

Keywords: Bacterial biofilm; Colorectal cancer; Enterotoxigenic Bacteroides fragilis; Fusobacterium-adhesin A; Genotoxinʼ; N 1; N 12–diacetylspermine; Therapy; s coli bactin.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest Nothing declared.

Cited by

From random to precise: updated colon cancer screening and surveillance for inflammatory bowel disease.
Fatakhova K, Rajapakse R. Fatakhova K, et al. Transl Gastroenterol Hepatol. 2024 Apr 17;9:27. doi: 10.21037/tgh-23-36. eCollection 2024. Transl Gastroenterol Hepatol. 2024. PMID: 38716215 Free PMC article. Review.
The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis.
Conde-Pérez K, Aja-Macaya P, Buetas E, Trigo-Tasende N, Nasser-Ali M, Rumbo-Feal S, Nión P, Arribas EM, Estévez LS, Otero-Alén B, Noguera JF, Concha Á, Pardiñas-López S, Carda-Diéguez M, Gómez-Randulfe I, Martínez-Lago N, Ladra S, Aparicio LMA, Bou G, Mira Á, Vallejo JA, Poza M. Conde-Pérez K, et al. Mol Oncol. 2024 May;18(5):1093-1122. doi: 10.1002/1878-0261.13604. Epub 2024 Feb 17. Mol Oncol. 2024. PMID: 38366793 Free PMC article.
Colon Cancer Microbiome Landscaping: Differences in Right- and Left-Sided Colon Cancer and a Tumor Microbiome-Ileal Microbiome Association.
Kneis B, Wirtz S, Weber K, Denz A, Gittler M, Geppert C, Brunner M, Krautz C, Siebenhüner AR, Schierwagen R, Tyc O, Agaimy A, Grützmann R, Trebicka J, Kersting S, Langheinrich M. Kneis B, et al. Int J Mol Sci. 2023 Feb 7;24(4):3265. doi: 10.3390/ijms24043265. Int J Mol Sci. 2023. PMID: 36834671 Free PMC article.
Immunometabolism in biofilm infection: lessons from cancer.
Mirzaei R, Sabokroo N, Ahmadyousefi Y, Motamedi H, Karampoor S. Mirzaei R, et al. Mol Med. 2022 Jan 29;28(1):10. doi: 10.1186/s10020-022-00435-2. Mol Med. 2022. PMID: 35093033 Free PMC article. Review.
Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4.
Serna N, Carratalá JV, Conchillo-Solé O, Martínez-Torró C, Unzueta U, Mangues R, Ferrer-Miralles N, Daura X, Vázquez E, Villaverde A. Serna N, et al. Pharmaceutics. 2021 Nov 13;13(11):1922. doi: 10.3390/pharmaceutics13111922. Pharmaceutics. 2021. PMID: 34834337 Free PMC article.

See all "Cited by" articles

Publication types

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Affiliations

Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

Publication types

LinkOut - more resources

Full Text Sources