Humanized mice as preclinical models for myeloid malignancies
- PMID: 31926939
- DOI: 10.1016/j.bcp.2020.113794
Humanized mice as preclinical models for myeloid malignancies
Abstract
Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools to dissect disease biology and to bridge the gap between pre-clinical testing of novel therapeutics and their clinical applications. Many efforts have been placed to advance and optimize humanized mice to support the engraftment, differentiation, and maintenance of hematopoietic stem cells (HSCs) and the human hematological system in order to broaden the scope of applications of such models. This review covers the background of humanized mice, how they are used as platforms to model myeloid malignancies, and the various current and potential approaches to further enhance their utilization in biomedical research.
Keywords: Cytokine humanization; Humanized mice; Immunodeficient mouse models; Myeloid malignancy; Pre-clinical studies; Xenotransplantation.
Copyright © 2020 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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