Mitochondrial dysfunction and oxidative stress in heart disease
- PMID: 31857574
- PMCID: PMC6923355
- DOI: 10.1038/s12276-019-0355-7
Mitochondrial dysfunction and oxidative stress in heart disease
Abstract
Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players in molecular signaling and cell fate determination through reactive oxygen species (ROS). While ROS production has historically been portrayed as an unregulated process driving oxidative stress and disease pathology, contemporary studies reveal that ROS also facilitate normal physiology. Mitochondria are especially abundant in cardiac tissue; hence, mitochondrial dysregulation and ROS production are thought to contribute significantly to cardiac pathology. Moreover, there is growing appreciation that medical therapies designed to mediate mitochondrial ROS production can be important strategies to ameliorate cardiac disease. In this review, we highlight evidence from animal models that illustrates the strong connections between mitochondrial ROS and cardiac disease, discuss advancements in the development of mitochondria-targeted antioxidant therapies, and identify challenges faced in bringing such therapies into the clinic.
Conflict of interest statement
The authors declare that they have no conflict of interest.
Figures
![Fig. 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6923355/bin/12276_2019_355_Fig1_HTML.gif)
![Fig. 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/6923355/bin/12276_2019_355_Fig2_HTML.gif)
Similar articles
-
Assessment of mitochondrial dysfunction and implications in cardiovascular disorders.Life Sci. 2022 Oct 1;306:120834. doi: 10.1016/j.lfs.2022.120834. Epub 2022 Jul 25. Life Sci. 2022. PMID: 35902031 Review.
-
The potential mechanism of mitochondrial dysfunction in septic cardiomyopathy.J Int Med Res. 2018 Jun;46(6):2157-2169. doi: 10.1177/0300060518765896. Epub 2018 Apr 11. J Int Med Res. 2018. PMID: 29637807 Free PMC article.
-
Metabolic reprogramming of human cells in response to oxidative stress: implications in the pathophysiology and therapy of mitochondrial diseases.Curr Pharm Des. 2014;20(35):5510-26. doi: 10.2174/1381612820666140306103401. Curr Pharm Des. 2014. PMID: 24606797 Review.
-
Mitochondrial biogenesis: pharmacological approaches.Curr Pharm Des. 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. Curr Pharm Des. 2014. PMID: 24606795
-
Oxidative stress precedes skeletal muscle mitochondrial dysfunction during experimental aortic cross-clamping but is not associated with early lung, heart, brain, liver, or kidney mitochondrial impairment.J Vasc Surg. 2014 Oct;60(4):1043-51.e5. doi: 10.1016/j.jvs.2013.07.100. Epub 2013 Oct 3. J Vasc Surg. 2014. PMID: 24095040
Cited by
-
Aerobic Exercise Ameliorates Cognitive Disorder and Declined Oxidative Stress via Modulating the Nrf2 Signaling Pathway in D-galactose Induced Aging Mouse Model.Neurochem Res. 2024 Jun 6. doi: 10.1007/s11064-024-04164-2. Online ahead of print. Neurochem Res. 2024. PMID: 38839706
-
Mitophagy in relation to chronic inflammation/ROS in aging.Mol Cell Biochem. 2024 Jun 4. doi: 10.1007/s11010-024-05042-9. Online ahead of print. Mol Cell Biochem. 2024. PMID: 38834837 Review.
-
The Role of Oxidative Stress and Inflammatory Parameters in Heart Failure.Medicina (Kaunas). 2024 May 2;60(5):760. doi: 10.3390/medicina60050760. Medicina (Kaunas). 2024. PMID: 38792942 Free PMC article. Review.
-
IL-37 ameliorates myocardial fibrosis by regulating mtDNA-enriched vesicle release in diabetic cardiomyopathy mice.J Transl Med. 2024 May 24;22(1):494. doi: 10.1186/s12967-024-05250-3. J Transl Med. 2024. PMID: 38790051 Free PMC article.
-
The role of IFI16 in regulating PANoptosis and implication in heart diseases.Cell Death Discov. 2024 May 1;10(1):204. doi: 10.1038/s41420-024-01978-5. Cell Death Discov. 2024. PMID: 38693141 Free PMC article. Review.
References
-
- Misra MK, Sarwat M, Bhakuni P, Tuteja R, Tuteja N. Oxidative stress and ischemic myocardial syndromes. Med. Sci. Monit. 2009;15:RA209–RA219. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical