Targeting senescent cells in translational medicine
- PMID: 31746100
- PMCID: PMC6895604
- DOI: 10.15252/emmm.201810234
Targeting senescent cells in translational medicine
Abstract
Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.
Keywords: SASP; age-related disorders; cellular senescence; senolytic drugs; senoprobes.
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
Conflict of interest statement
The authors declare that they have no conflict of interest.
Figures
Similar articles
-
Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies.Cells. 2023 Mar 16;12(6):915. doi: 10.3390/cells12060915. Cells. 2023. PMID: 36980256 Free PMC article. Review.
-
Cellular senescence in ageing: from mechanisms to therapeutic opportunities.Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. doi: 10.1038/s41580-020-00314-w. Epub 2020 Dec 16. Nat Rev Mol Cell Biol. 2021. PMID: 33328614 Free PMC article. Review.
-
Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells.Front Endocrinol (Lausanne). 2022 Mar 31;13:869414. doi: 10.3389/fendo.2022.869414. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35432205 Free PMC article. Review.
-
From Development to Aging: The Path to Cellular Senescence.Antioxid Redox Signal. 2021 Feb 1;34(4):294-307. doi: 10.1089/ars.2020.8071. Epub 2020 May 5. Antioxid Redox Signal. 2021. PMID: 32228062 Free PMC article. Review.
-
Cellular senescence in bone.Bone. 2019 Apr;121:121-133. doi: 10.1016/j.bone.2019.01.015. Epub 2019 Jan 16. Bone. 2019. PMID: 30659978 Free PMC article. Review.
Cited by
-
Prototyping an Ontological Framework for Cellular Senescence Mechanisms: A Homeostasis Imbalance Perspective.Sci Data. 2024 May 10;11(1):485. doi: 10.1038/s41597-024-03331-y. Sci Data. 2024. PMID: 38729991 Free PMC article.
-
Delineating the heterogeneity of senescence-induced-functional alterations in hepatocytes.Cell Mol Life Sci. 2024 Apr 30;81(1):200. doi: 10.1007/s00018-024-05230-2. Cell Mol Life Sci. 2024. PMID: 38684535 Free PMC article.
-
Human Papillomavirus Is Rare and Does Not Correlate with p16INK4A Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation.Medicina (Kaunas). 2024 Apr 19;60(4):660. doi: 10.3390/medicina60040660. Medicina (Kaunas). 2024. PMID: 38674306 Free PMC article.
-
Cellular senescence in cancer: molecular mechanisms and therapeutic targets.MedComm (2020). 2024 Apr 24;5(5):e542. doi: 10.1002/mco2.542. eCollection 2024 May. MedComm (2020). 2024. PMID: 38660685 Free PMC article. Review.
-
Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.Nat Commun. 2024 Apr 5;15(1):2939. doi: 10.1038/s41467-024-47317-1. Nat Commun. 2024. PMID: 38580630 Free PMC article.
References
-
- Abad M, Mosteiro L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megías D, Domínguez O, Martínez D et al (2013) Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502: 340–345 - PubMed
-
- Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N et al (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 133: 1006–1018 - PubMed
-
- Agostini A, Mondragõn L, Bernardos A, Martínez‐Máñez R, Dolores Marcos M, Sancenõn F, Soto J, Costero A, Manguan‐García C, Perona R et al (2012) Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles. Angew Chem Int Ed 51: 10556–10560 - PubMed
-
- Akbar AN, Henson SM, Lanna A (2016) Senescence of T lymphocytes: implications for enhancing human immunity. Trends Immunol 37: 866–876 - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical