Review

. 2020 Feb:501:112-119.

doi: 10.1016/j.cca.2019.10.028. Epub 2019 Nov 9.

Electrochemical detection of serotonin: A new approach

Kamyar Khoshnevisan¹, Elham Honarvarfard², Farzad Torabi³, Hassan Maleki⁴, Hadi Baharifar⁵, Farnoush Faridbod⁴, Bagher Larijani⁶, Mohammad Reza Khorramizadeh⁷

Affiliations

¹ Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: k-khoshnevisan@razi.tums.ac.ir.
² Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA.
³ School of Chemistry, College of Science, University of Tehran, Tehran, Iran; Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
⁴ Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
⁶ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: khoramza@tums.ac.ir.

PMID: 31715139
DOI: 10.1016/j.cca.2019.10.028

Review

Electrochemical detection of serotonin: A new approach

Kamyar Khoshnevisan et al. Clin Chim Acta. 2020 Feb.

. 2020 Feb:501:112-119.

doi: 10.1016/j.cca.2019.10.028. Epub 2019 Nov 9.

Authors

Kamyar Khoshnevisan¹, Elham Honarvarfard², Farzad Torabi³, Hassan Maleki⁴, Hadi Baharifar⁵, Farnoush Faridbod⁴, Bagher Larijani⁶, Mohammad Reza Khorramizadeh⁷

Affiliations

¹ Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: k-khoshnevisan@razi.tums.ac.ir.
² Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA.
³ School of Chemistry, College of Science, University of Tehran, Tehran, Iran; Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
⁴ Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.
⁶ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: khoramza@tums.ac.ir.

PMID: 31715139
DOI: 10.1016/j.cca.2019.10.028

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter which plays a significant role in various functions in the body, such as appetite, emotions, and autonomic functions. It is well known that biomarker 5-HT levels can be correlated to several diseases and disorders such as depression, anxiety, irritable bowel, and sleep trouble. Among various methods for detecting the 5-HT biomarker, electrochemical techniques have attracted great interest due to their low cost and ease of operation. However, sensitive and precise electrochemical detection of 5-HT levels is not possible using bare electrodes, thus requiring electrode modification. The present review aims to describe the different electroanalytical methods for 5-HT detection using various surface-modified electrodes such as glassy carbon, carbon fiber, diamond, graphite, and metal electrodes modified with conductive polymers. Perspectives and the modification of electrode surface using applied polymers for 5-HT detection have also been presented.

Keywords: Biomarker; Conductive polymers; Electrochemical sensing; Glassy carbon electrode; Polymer modification; Serotonin.

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Electrochemical detection of serotonin: A new approach

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Electrochemical detection of serotonin: A new approach

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