Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats
- PMID: 31655149
- DOI: 10.1016/j.jep.2019.112331
Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats
Abstract
Ethnopharmacological relevance: Undesired effects of synthetic antidiabetic agents have made researchers to seek for safer and healthier resources. With this aspect, herbal materials have attracted substantial research interest and are being extensively investigated. Considering that herb-drug interactions can be a double-edged sword presenting both risks and benefits, investigation of such interactions is greatly in demand.
Aim of the study: to investigate possible beneficial effects of hydroalcoholic extract of SecurigeraSecuridaca seed (HESS) on antioxidant capacity, fibroblast growth factor 21 (FGF21) and insulin resistance in Streptozotocin (STZ)-induced diabetic rats, alone and in combination with glibenclamide.
Materials and methods: Forty male Wistar rats were randomly divided in to eight equal groups including healthy and diabetic controls and six treated groups with a various doses of HESS alone and in combination with glibenclamide, for 35 consecutive days. Serum samples were taken and analyzed for biochemical profile, HOMA indexes, FGF21, oxidative/nitrosative stress and inflammatory biomarkers as compared with the controls. Moreover, total phenolic and flavonoid contents of herbal extract were assessed.
Results: The herbal extract was found to be rich in flavonoid and phenolic components. Both of glibenclamide and the HESS decreased glucose and insulin resistance, as well as increased body weight and insulin sensitivity. Moreover, the extract could mitigate oxidative/nitrosative stress and inflammation dose-dependently, however, the standard drug was less effective than HESS. Induction of diabetes increased FGF21 levels and both of the treatments could reduce its contents, however, glibenclamide was more effective than HESS.
Conclusions: The results clearly show that there is no contradiction between HESS and glibenclamide. Moreover, the herbal extract could augment antioxidant and anti-inflammatory properties of the standard drug.
Keywords: Antioxidant; Diabetes; FGF21; Glibenclamide; Securigera Securidaca.
Copyright © 2019 Elsevier B.V. All rights reserved.
Similar articles
-
Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.Reprod Biol Endocrinol. 2021 Jul 7;19(1):104. doi: 10.1186/s12958-021-00794-1. Reprod Biol Endocrinol. 2021. PMID: 34233693 Free PMC article.
-
Antidepressant activity of anti-hyperglycemic agents in experimental models: A review.Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1179-1186. doi: 10.1016/j.dsx.2020.06.021. Epub 2020 Jul 7. Diabetes Metab Syndr. 2020. PMID: 32673838 Review.
-
Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies.Nutrients. 2019 Dec 25;12(1):58. doi: 10.3390/nu12010058. Nutrients. 2019. PMID: 31881654 Free PMC article. Review.
-
Evaluation of the antidiabetic and antioxidant properties of Morinda lucida stem bark extract in streptozotocin intoxicated rats.Pak J Pharm Sci. 2016 May;29(3):903-11. Pak J Pharm Sci. 2016. PMID: 27166555
-
Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats.Pharm Biol. 2016 Sep;54(9):1716-26. doi: 10.3109/13880209.2015.1125932. Epub 2015 Dec 24. Pharm Biol. 2016. PMID: 26704340
Cited by
-
Evaluation of serum pro/anti-angiogenic biomarkers in hyperglycemic rats treated with Securigera securidaca seeds, alone and in combination with Glibenclamide.J Cardiovasc Thorac Res. 2024;16(1):8-14. doi: 10.34172/jcvtr.32960. Epub 2024 Mar 13. J Cardiovasc Thorac Res. 2024. PMID: 38584657 Free PMC article.
-
Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model.Oxid Med Cell Longev. 2023 Jan 7;2023:7285036. doi: 10.1155/2023/7285036. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 36647426 Free PMC article.
-
The Protective Effects of Securigera securidaca Seed Extract on Liver Injury Induced by Bile Duct Ligation in Rats.Biomed Res Int. 2022 Feb 4;2022:6989963. doi: 10.1155/2022/6989963. eCollection 2022. Biomed Res Int. 2022. PMID: 35155679 Free PMC article.
-
Glibenclamide Ameliorates the Expression of Neurotrophic Factors in Sevoflurane Anaesthesia-induced Oxidative Stress and Cognitive Impairment in Hippocampal Neurons of Old Rats.J Vet Res. 2021 Dec 2;65(4):527-538. doi: 10.2478/jvetres-2021-0064. eCollection 2021 Dec. J Vet Res. 2021. PMID: 35112009 Free PMC article.
-
Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide.Reprod Biol Endocrinol. 2021 Jul 7;19(1):104. doi: 10.1186/s12958-021-00794-1. Reprod Biol Endocrinol. 2021. PMID: 34233693 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials