Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD)
- PMID: 31176163
- DOI: 10.1016/j.biopha.2019.109047
Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD)
Abstract
NAFLD is a vital health problem worldwide; however, no effective treatment is currently available for NAFLD. Intensive studies have indicated the efficacy of genistein (GE), a bioactive isoflavone extracted from soy, in treating NAFLD. In addition to its oestrogen-like effects, GE is known to have multiple molecular effects, for instance, lipid and glucose metabolism-promoting effects and activities against lipid peroxidation, inflammation, fibrosis, and NAFLD-related tumours. Here, this review summarizes the potential role of GE in the treatment and prevention of NAFLD and some of the currently known targets and signalling pathways of GE in NAFLD.
Keywords: Genistein; Non-alcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Review; Soy.
Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Similar articles
-
MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice.Int J Mol Sci. 2019 Dec 3;20(23):6084. doi: 10.3390/ijms20236084. Int J Mol Sci. 2019. PMID: 31816816 Free PMC article.
-
Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXRα, PPARγ, and NF-κB-iNOS-NO signaling pathways.J Ethnopharmacol. 2019 May 23;236:316-325. doi: 10.1016/j.jep.2019.03.006. Epub 2019 Mar 6. J Ethnopharmacol. 2019. PMID: 30851372
-
Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease.Mol Nutr Food Res. 2018 Jan;62(1):1700483. doi: 10.1002/mnfr.201700483. Epub 2017 Oct 12. Mol Nutr Food Res. 2018. PMID: 28799714 Free PMC article. Review.
-
Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice.Biol Pharm Bull. 2015;38(7):1005-11. doi: 10.1248/bpb.b14-00892. Epub 2015 May 12. Biol Pharm Bull. 2015. PMID: 25972092
-
Current pharmacological therapies for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.World J Gastroenterol. 2015 Apr 7;21(13):3777-85. doi: 10.3748/wjg.v21.i13.3777. World J Gastroenterol. 2015. PMID: 25852263 Free PMC article. Review.
Cited by
-
The Role of Choline, Soy Isoflavones, and Probiotics as Adjuvant Treatments in the Prevention and Management of NAFLD in Postmenopausal Women.Nutrients. 2023 Jun 8;15(12):2670. doi: 10.3390/nu15122670. Nutrients. 2023. PMID: 37375574 Free PMC article. Review.
-
EGF-receptor phosphorylation and downstream signaling are activated by genistein during subacute liver damage.J Mol Histol. 2023 Jun;54(3):231-244. doi: 10.1007/s10735-023-10127-8. Epub 2023 May 25. J Mol Histol. 2023. PMID: 37227557 Free PMC article.
-
Nutritional Genomics in Nonalcoholic Fatty Liver Disease.Biomedicines. 2023 Jan 23;11(2):319. doi: 10.3390/biomedicines11020319. Biomedicines. 2023. PMID: 36830856 Free PMC article. Review.
-
Qushi Huayu decoction attenuated hepatic lipid accumulation via JAK2/STAT3/CPT-1A-related fatty acid β-oxidation in mice with non-alcoholic steatohepatitis.Pharm Biol. 2022 Dec;60(1):2124-2133. doi: 10.1080/13880209.2022.2134898. Pharm Biol. 2022. PMID: 36308318 Free PMC article.
-
Genistein improves mitochondrial function and inflammatory in rats with diabetic nephropathy via inhibiting MAPK/NF-κB pathway.Acta Cir Bras. 2022 Aug 15;37(6):e370601. doi: 10.1590/acb370601. eCollection 2022. Acta Cir Bras. 2022. PMID: 35976278 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
