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Review
. 2020 Jan;71(1):17-26.
doi: 10.1177/0003319719849737. Epub 2019 May 26.

Premature Myocardial Infarction in the Middle East and North Africa: Rationale for the Gulf PREVENT Study

Sagar B Dugani  1   2 , Waheed Murad  3 , Karisamae Damilig  3 , Jean Atos  3 , Eshraga Mohamed  3 , Edward Callachan  4 , Zareen Farukhi  2 , Arshia Shaikh  3 , Abubaker Elfatih  5 , Salwa Yusef  5 , Yousif M Hydoub  6 , M Vinayaga Moorthy  2 , Bassem Mora  3 , Ahlam Alawadhi  3 , Robin Issac  3 , Abdulkarim Saleh  7 , Arif Al-Mulla  3 , Samia Mora  2   8   9 , Alawi A Alsheikh-Ali  3   10   9
Affiliations
Review

Premature Myocardial Infarction in the Middle East and North Africa: Rationale for the Gulf PREVENT Study

Sagar B Dugani et al. Angiology. 2020 Jan.

Abstract

The Middle East and North Africa (MENA) region has a high burden of morbidity and mortality due to premature (≤55 years in men; ≤65 years in women) myocardial infarction (MI) and acute coronary syndrome (ACS). Despite this, the prevalence of risk factors in patients presenting with premature MI or ACS is incompletely described. We compared lifestyle, clinical risk factors, and biomarkers associated with premature MI/ACS in the MENA region with selected non-MENA high-income countries. We identified English-language, peer-reviewed publications through PubMed (up to March 2018). We used the World Bank classification system to categorize countries. Patients with premature MI/ACS in the MENA region had a higher prevalence of smoking than older patients with MI/ACS but a lower prevalence of diabetes, hypertension, and dyslipidemia. Men with premature MI/ACS had a higher prevalence of smoking than women but a lower prevalence of diabetes and hypertension. The MENA region had sparse data on lifestyle, diet, psychological stress, and physical activity. To address these knowledge gaps, we initiated the ongoing Gulf Population Risks and Epidemiology of Vascular Events and Treatment (Gulf PREVENT) case-control study to improve primary and secondary prevention of premature MI in the United Arab Emirates, a high-income country in the MENA region.

Keywords: MENA; United Arab Emirates; biomarkers; cardiovascular disease; ischemic heart disease; premature myocardial infarction; risk factors.

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Conflict of interest statement

Declaration of interest: the authors do not have any conflicts of interest

Figures

Figure 1:
Figure 1:
Middle East and North Africa region with middle- (light grey) and high-income (dark grey) countries.
Figure 2:
Figure 2:
Schematic of Gulf PREVENT, ongoing case-control study on premature MI in Abu Dhabi, United Arab Emirates. Gulf PREVENT: Gulf Population Risks and Epidemiology of Vascular Events and Treatment; MI: myocardial infarction.
See this image and copyright information in PMC

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References

    1. Roth GA, Johnson C, Abajobir A, et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70:1–25. - PMC - PubMed
    1. Roth GA, Forouzanfar MH, Moran AE, et al. Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality. N Engl J Med. 2015;372:1333–41. - PMC - PubMed
    1. Roth GA, Nguyen G, Forouzanfar MH, Mokdad AH, Naghavi M, Murray CJL. Estimates of Global and Regional Premature Cardiovascular Mortality in 2025. Circulation. 2015;132:1270–82. - PubMed
    1. World Bank Group. World Bank country and lending groups. https://data.worldbank.org/region/middle-east-and-north-africa?view=chart. Published 2018. Accessed April 26, 2018.
    1. Mokdad AH, Mokdad AH. Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990–2015: findings from the Global Burden of Disease 2015 study. Int J Public Health. 2018;63(Suppl 1):137–49. - PMC - PubMed

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