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. 2019 May 17;9(1):7560.
doi: 10.1038/s41598-019-43864-6.

Several biological benefits of the low color temperature light-emitting diodes based normal indoor lighting source

Jiaqi Lin  1 , Xingwei Ding  1 , Can Hong  1 , Yulian Pang  2 , Liming Chen  1 , Quanwen Liu  1 , Xu Zhang  2 , Hongbo Xin  1 , Xiaolei Wang  3
Affiliations

Several biological benefits of the low color temperature light-emitting diodes based normal indoor lighting source

Jiaqi Lin et al. Sci Rep. .

Abstract

Currently, light pollution has become a nonnegligible issue in our daily life. Artificial light sources with high color temperature were deem to be the major pollution source, which could induce several adverse effects on human's health. In our previous research, we have firstly developed an artificial indoor light with low color temperature (1900 K). However, the biological effects of this artificial light on human's health are unclear. Here, four artificial lights (1900 K, 3000 K, 4000 K and 6600 K) were used to evaluate some biological changes in both human (in total 152 person-times) and murine models. Compared with other three high color temperature artificial lights, our lights (1900 K) presented a positive effect on promoting the secreting of melatonin and glutamate, protecting human's eyes, accelerating would healing and hair regeneration. These systematical studies indicated that the proposed low color temperature (1900 K) light could provide several significant benefits in human's daily life.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
(a) Schematic illustration of the relationships between sun and human’s biological rhythm. (b–e) The electro-luminance spectra and CIE1931 chromaticity diagrams of 4 different color temperature lights (1900 K, 3000 K, 4000 K, and 6600 K)were characterized by integrating sphere. The electro-luminance spectra and CIE1931 chromaticity diagrams of four artificial lights with different color temperature (1900 K, 3000 K, 4000 K, and 6600 K) were characterized by integrating sphere.
Figure 2
Figure 2
(a) The melatonin secretion from volunteers treated with artificial lights (1900 K, 3000 K, 4000 K and 6600 K) for 2 h (n ≥ 30). (b–e) The melatonin level of volunteers treated with artificial lights (1900 K, 3000 K, 4000 K and 6600 K) at the desired time (n ≥ 10). (f) The glutamate level of volunteers treated with artificial lights (1900 K, 3000 K, 4000 K and 6600 K) for 2 h (n ≥ 30) ***P < 0.001.
Figure 3
Figure 3
The biological effect on human’s eyes before and after irradiation by artificial lights (1900 K, 3000 K, 4000 K and 6600 K), the experiment was repeated by three times at different time. (a) The first non-invasive tear break-up time. (b) The average non-invasive tear break-up time. (c) The tear meniscus height. (d) The red eye analysis (B grading). (e) The red eye analysis (L grading).
Figure 4
Figure 4
(a) The murine wound models were treated with different artificial lights (1900 K, 3000 K, 4000 K and 6600 K). (b) The human’s skin was irradiated by different artificial lights after being treated with microneedles (Scale bar: 20 μm). (c) The wound healing time of mice (n ≥ 3). (d) The wound healing time of human (n ≥ 4) ***P < 0.001.
Figure 5
Figure 5
The hair regeneration assessment in murine alopecia model, the area of mice was irradiated by different artificial lights (1900 K, 3000 K, 4000 K and 6600 K) after being treated with stem cells growth factors (n ≥ 3) (Scale bar: 20 μm).
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