Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101
- PMID: 30624788
- PMCID: PMC6593808
- DOI: 10.1111/cod.13210
Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101
Abstract
Background: The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing.
Objectives: To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy.
Methods: A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate.
Results: Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001).
Conclusions: The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.
Keywords: Amerchol L-101; cetyl alcohol; contact allergy; lanolin alcohol; patch testing; vehicle; wool alcohols.
© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors have no conflicts of interest to report.
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References
-
- Johansen JD, Frosch PJ, Lepoittevin L‐P. Contact Dermatitis. 5th ed. Berlin, Heidelberg: Springer‐Verlag; 2011.
-
- Lee B, Warshaw E. Lanolin allergy: history, epidemiology, responsible allergens, and management. Dermatitis. 2008;19:63‐72. - PubMed
-
- Schlossman ML, Mccarthy JP. Lanolin and derivatives chemistry: relationship to allergic contact dermatitis. Contact Dermatitis. 1979;5:65‐72. - PubMed
-
- Warshaw EM, Nelsen DD, Maibach HI, et al. Positive patch test reactions to lanolin: cross‐sectional data from the North American Contact Dermatitis Group, 1994 to 2006. Dermatitis. 2009;20:79‐88. - PubMed
-
- Thyssen JP, Mcfadden JP, Kimber I. The multiple factors affecting the association between atopic dermatitis and contact sensitization. Allergy. 2014;69:28‐36. - PubMed
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