A systematic review and a dose-response meta-analysis of coffee dose and nonalcoholic fatty liver disease
- PMID: 30573353
- DOI: 10.1016/j.clnu.2018.11.030
A systematic review and a dose-response meta-analysis of coffee dose and nonalcoholic fatty liver disease
Abstract
Objective: Nonalcoholic fatty liver disease (NAFLD) is the most predominant chronic liver disease worldwide. Effect of coffee on NAFLD risk and its potential dose-response patterns were explored in the study.
Design: PubMed, Web of Science, MEDLINE, Cochrane and Embase were searched up to 10 April 2018. We performed pair-wise meta-analysis of <1 cup per day vs. 1-2 cups per days or >2 cups per day to pool the relative risks (RRs) and corresponding 95% confidence intervals (CIs). And dose-response analysis was used to estimate relationship of NAFLD occurrence with coffee intake.
Results: Seven articles were included with 4825 cases and 49,616 non-cases. Compared with <1 cup, 1-2 cups or >2 cups of coffee consumption per day were not significantly associated with NAFLD occurrence, and RR were 0.97 (95% CI: 0.85-1.11) and 0.88 (95%CI: 0.72-1.06). However, the summary RR of the highest versus lowest coffee consumption was 0.94 (95% CI: 0.92-0.97). Dose-response meta-analysis presented a non-linearity curve relationship of coffee and NAFLD occurrence while coffee consumption >3 cups per day reduced NAFLD significantly.
Conclusion: Coffee intake level more than 3 cups was observed lower risk of NAFLD than <2 cups per day. Although the risk of NAFLD was inversely associated with coffee consumption, while relevance may not be very close and more observational studies would be needed to verify the relationship of coffee and NAFLD.
Keywords: Coffee; Dose–response; Meta-analysis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis.
Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Similar articles
-
Association between processed and unprocessed red meat consumption and risk of nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis.J Glob Health. 2024 Apr 26;14:04060. doi: 10.7189/jogh.14.04060. J Glob Health. 2024. PMID: 38665062 Free PMC article.
-
Effect of Coffee Consumption on Non-Alcoholic Fatty Liver Disease Incidence, Prevalence and Risk of Significant Liver Fibrosis: Systematic Review with Meta-Analysis of Observational Studies.Nutrients. 2021 Aug 30;13(9):3042. doi: 10.3390/nu13093042. Nutrients. 2021. PMID: 34578919 Free PMC article.
-
The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: A meta-analysis of 11 epidemiological studies.Ann Hepatol. 2021 Jan-Feb;20:100254. doi: 10.1016/j.aohep.2020.08.071. Epub 2020 Sep 10. Ann Hepatol. 2021. PMID: 32920163
-
Coffee consumption and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis.Eur J Gastroenterol Hepatol. 2017 Feb;29(2):e8-e12. doi: 10.1097/MEG.0000000000000776. Eur J Gastroenterol Hepatol. 2017. PMID: 27824642 Review.
-
Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies.Clin Nutr. 2016 Dec;35(6):1269-1281. doi: 10.1016/j.clnu.2016.03.012. Epub 2016 Mar 30. Clin Nutr. 2016. PMID: 27060021 Review.
Cited by
-
Lifestyle intervention for metabolic dysfunction-associated fatty liver disease: a 24-h integrated behavior perspective.Hepatol Int. 2024 May 8. doi: 10.1007/s12072-024-10663-9. Online ahead of print. Hepatol Int. 2024. PMID: 38717691
-
The Relationship between Pathogenesis and Possible Treatments for the MASLD-Cirrhosis Spectrum.Int J Mol Sci. 2024 Apr 16;25(8):4397. doi: 10.3390/ijms25084397. Int J Mol Sci. 2024. PMID: 38673981 Free PMC article. Review.
-
Association between processed and unprocessed red meat consumption and risk of nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis.J Glob Health. 2024 Apr 26;14:04060. doi: 10.7189/jogh.14.04060. J Glob Health. 2024. PMID: 38665062 Free PMC article.
-
Understanding the Burden of Nonalcoholic Fatty Liver Disease: Time for Action.Diabetes Spectr. 2024 Winter;37(1):9-19. doi: 10.2337/dsi23-0010. Epub 2024 Feb 15. Diabetes Spectr. 2024. PMID: 38385101 Free PMC article.
-
Beverage consumption in patients with metabolic syndrome and its association with non-alcoholic fatty liver disease: a cross-sectional study.Front Nutr. 2024 Jan 22;11:1257969. doi: 10.3389/fnut.2024.1257969. eCollection 2024. Front Nutr. 2024. PMID: 38318474 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous